HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: SIR7 (Q9NRC8)
NAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7)
Gene: SIRT7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28886238
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006281 - DNA repair GO:0006974 - DNA damage response
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 759 Hs			1 400
+	Hs
		1043606 CUL4B_HUMAN (10-759): 0: 927: 82.31		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1043093 CUL4A_HUMAN (1-759): 0: 963: 100.00		SIR2_HUMAN (75-380): 1.48e-97: 298: 21.26
+	Hs
		1043158 CUL4A_HUMAN (1-759): 0: 963: 100.00		SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94
+	Hs
		1043511 CUL4B_HUMAN (10-759): 0: 927: 82.31		SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94
+	Hs
		1042252 CUL3_HUMAN (32-759): 0: 814: 38.23		SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94