HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: WSB1 (Q9Y6I7)
WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box-containing WD protein SWiP-1)
Gene: WSB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	36688959, 17079684
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 759 Hs			1 421
+	Hs
		792982 CUL4A_HUMAN (1-759): 0: 963: 100.00		LIS1_HUMAN (2-286): 2.98e-83: 262: 20.72
+	Hs
		1043157 CUL4A_HUMAN (1-759): 0: 963: 100.00		SNR40_HUMAN (2-282): 1.31e-65: 215: 20.42
+	Hs
		1043499 CUL4B_HUMAN (10-759): 0: 927: 82.31		FBXW7_HUMAN (2-334): 4.09e-75: 249: 19.05
+	Hs
		1043114 CUL4A_HUMAN (1-759): 0: 963: 100.00		POC1B_HUMAN (205-421): 5.6e-60: 204: 21.17
+	Hs
		1043509 CUL4B_HUMAN (10-759): 0: 927: 82.31		SNR40_HUMAN (2-282): 1.31e-65: 215: 20.42
+	Hs
		1043469 CUL4B_HUMAN (10-759): 0: 927: 82.31		POC1B_HUMAN (205-421): 5.6e-60: 204: 21.17
+	Hs
		863425 CUL4A_HUMAN (1-759): 0: 963: 100.00		COPA_HUMAN (206-381): 7.82e-34: 136: 18.54
+	Hs
		903208 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDR5_HUMAN (295-420): 1.65e-30: 121: 15.27
+	Hs
		1043262 CUL4A_HUMAN (1-759): 0: 963: 100.00		WSB2_HUMAN (2-198): 1.18e-28: 117: 15.50
+	Hs
		1043085 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDR5B_HUMAN (285-420): 5.67e-27: 111: 13.48
+	Hs
		903209 CUL4B_HUMAN (10-759): 0: 927: 82.31		WDR5_HUMAN (295-420): 1.65e-30: 121: 15.27
+	Hs
		1043441 CUL4B_HUMAN (10-759): 0: 927: 82.31		WDR5B_HUMAN (285-420): 5.67e-27: 111: 13.48
+	Hs
		1042101 CUL3_HUMAN (32-759): 0: 814: 38.23		POC1B_HUMAN (205-421): 5.6e-60: 204: 21.17
+	Hs
		245601 CUL4B_HUMAN (10-759): 0: 927: 82.31		TBL1X_HUMAN (289-418): 1.94e-18: 89.4: 13.42
+	Hs
		1043562 CUL4B_HUMAN (10-759): 0: 927: 82.31		TBL1R_HUMAN (289-418): 1.01e-17: 87.1: 14.19
+	Hs
		1041647 CUL3_HUMAN (32-759): 0: 814: 38.23		TAF5_HUMAN (206-382): 7.7e-36: 142: 20.08
+	Hs
		863424 CUL3_HUMAN (32-759): 0: 814: 38.23		COPA_HUMAN (206-381): 7.82e-34: 136: 18.54
+	Hs
		903207 CUL3_HUMAN (32-759): 0: 814: 38.23		WDR5_HUMAN (295-420): 1.65e-30: 121: 15.27
+	Hs
		1042655 CUL3_HUMAN (32-759): 0: 814: 38.23		NLE1_HUMAN (298-418): 5.4e-28: 117: 18.94
+	Hs
		903206 CUL1_HUMAN (59-759): 0: 745: 30.55		WDR5_HUMAN (295-420): 1.65e-30: 121: 15.27