HitPredict

Interactor 1: CUL4B (Q13620)
Cullin-4B (CUL-4B)
Gene: CUL4B

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	24292684, 27634302, 36517590, 23238014
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, chromatin immunoprecipitation assay, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 913 Hs			1 746
+	Mm
		1142296 CUL3_MOUSE (186-913): 0: 852: 37.19		EZH2_MOUSE (1-746): 0: 860: 98.39
+	Hs
		1041005 CUL1_HUMAN (213-913): 0: 778: 30.16		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1043519 CUL4B_HUMAN (1-913): 0: 1184: 100.00		NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82
+	Hs
		203680 CUL4B_HUMAN (1-913): 0: 1184: 100.00		SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90
+	At
		955876 CUL4_ARATH (147-913): 0: 919: 55.73		CLF_ARATH (248-733): 3.24e-95: 317: 28.36
+	Hs
		1042470 CUL3_HUMAN (186-913): 0: 853: 37.19		SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64
+	Hs
		1042562 CUL3_HUMAN (186-913): 0: 853: 37.19		EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27
+	Hs
		1042472 CUL3_HUMAN (186-913): 0: 853: 37.19		NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42
+	Hs
		1042298 CUL3_HUMAN (186-913): 0: 853: 37.19		EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21
+	Sp
		144463 CUL4_SCHPO (191-912): 0: 659: 33.65		CLR4_SCHPO (330-726): 8.94e-80: 265: 19.09
+	Hs
		975302 CUL5_HUMAN (213-913): 0: 610: 26.23		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54