HitPredict

Interactor 1: CUL4B (Q13620)
Cullin-4B (CUL-4B)
Gene: CUL4B

Interactor 2: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 28886238, 17392787, 30898011, 31911655, 33536335, 18593899, 35271311, 16964240, 16949367, 16678110, 19651607, 26496610, 27113764, 24292684, 16861906, 28446751, 28225217, 29738775, 29499938, 30945288 and 10 others

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Identification Methods affinity chromatography technology, pull down, two hybrid, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification, chromatin immunoprecipitation assay
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CPSF_A~Cullin, Cullin~MMS1_N
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0006974 - DNA damage response
GO:0010498 - proteasomal protein catabolic process
and 8 others

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Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 913
Hs

1 1140
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Dm
+ At
+ At
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Ce
+ Sp
+ Hs
+ Sp
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024