HitPredict

Interactor 1: CUL4B (Q13620)
Cullin-4B (CUL-4B)
Gene: CUL4B

Interactor 2: FBXW8 (Q8N3Y1)
F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)
Gene: FBXW8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	21145461
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Hs			1 598
+	Hs
		1043499 CUL4B_HUMAN (1-913): 0: 1184: 100.00		FBXW7_HUMAN (285-590): 1.43e-81: 272: 13.88
+	Hs
		245601 CUL4B_HUMAN (1-913): 0: 1184: 100.00		TBL1X_HUMAN (20-421): 1.03e-58: 207: 9.62
+	Hs
		1043441 CUL4B_HUMAN (1-913): 0: 1184: 100.00		WDR5B_HUMAN (40-372): 8.51e-54: 188: 13.41
+	Hs
		1043100 CUL4A_HUMAN (161-913): 0: 955: 81.83		FBXW8_HUMAN (1-598): 4.17e-132: 400: 96.17
+	Hs
		1043469 CUL4B_HUMAN (1-913): 0: 1184: 100.00		POC1B_HUMAN (428-590): 8.43e-39: 150: 15.39
+	Hs
		1043637 CUL4B_HUMAN (1-913): 0: 1184: 100.00		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Hs
		903209 CUL4B_HUMAN (1-913): 0: 1184: 100.00		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		1016274 CUL4B_HUMAN (1-913): 0: 1184: 100.00		TBL3_HUMAN (73-236): 2.09e-15: 81.8: 15.48
+	Hs
		1043562 CUL4B_HUMAN (1-913): 0: 1184: 100.00		TBL1R_HUMAN (62-239): 2.26e-13: 74.9: 14.05
+	Mm
		1206616 CUL3_MOUSE (186-913): 0: 852: 37.19		FBXW8_MOUSE (1-598): 4.1e-112: 349: 75.08
+	Hs
		1043085 CUL4A_HUMAN (161-913): 0: 955: 81.83		WDR5B_HUMAN (40-372): 8.51e-54: 188: 13.41
+	Hs
		792982 CUL4A_HUMAN (161-913): 0: 955: 81.83		LIS1_HUMAN (6-327): 3.89e-44: 164: 11.60
+	Hs
		1043114 CUL4A_HUMAN (161-913): 0: 955: 81.83		POC1B_HUMAN (428-590): 8.43e-39: 150: 15.39
+	Hs
		1043319 CUL4A_HUMAN (161-913): 0: 955: 81.83		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		1043297 CUL4A_HUMAN (161-913): 0: 955: 81.83		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Hs
		903208 CUL4A_HUMAN (161-913): 0: 955: 81.83		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		1042655 CUL3_HUMAN (186-913): 0: 853: 37.19		NLE1_HUMAN (374-598): 6.99e-46: 170: 10.26
+	Hs
		1042101 CUL3_HUMAN (186-913): 0: 853: 37.19		POC1B_HUMAN (428-590): 8.43e-39: 150: 15.39
+	Hs
		903207 CUL3_HUMAN (186-913): 0: 853: 37.19		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		1041848 CUL3_HUMAN (186-913): 0: 853: 37.19		TRAF7_HUMAN (257-500): 1.2e-22: 104: 17.38