HitPredict

Interactor 1: CUL4B (Q13620)
Cullin-4B (CUL-4B)
Gene: CUL4B

Interactor 2: WDTC1 (Q8N5D0)
WD and tetratricopeptide repeats protein 1
Gene: WDTC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.703

Property	Details
Experiments	27113764, 31973889, 33961781, 28514442
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Hs			1 677
+	Mm
		56799 CUL4B_MOUSE (36-913): 0: 1107: 97.28		WDTC1_MOUSE (1-677): 9.05e-131: 403: 93.66
+	Mm
		1111813 CUL4A_MOUSE (161-913): 0: 966: 81.96		WDTC1_MOUSE (1-677): 9.05e-131: 403: 93.66
+	Hs
		1043396 CUL4B_HUMAN (1-913): 0: 1184: 100.00		DCAF6_HUMAN (479-669): 8.52e-41: 161: 29.85
+	Hs
		473597 CUL4B_HUMAN (1-913): 0: 1184: 100.00		DC8L2_HUMAN (237-677): 5.12e-36: 145: 16.74
+	Hs
		1043405 CUL4B_HUMAN (1-913): 0: 1184: 100.00		DCAF8_HUMAN (511-677): 1.89e-31: 131: 29.15
+	Hs
		245601 CUL4B_HUMAN (1-913): 0: 1184: 100.00		TBL1X_HUMAN (84-378): 1.85e-27: 119: 10.65
+	Hs
		1043562 CUL4B_HUMAN (1-913): 0: 1184: 100.00		TBL1R_HUMAN (75-403): 1.35e-26: 116: 10.44
+	Hs
		1043469 CUL4B_HUMAN (1-913): 0: 1184: 100.00		POC1B_HUMAN (488-664): 5.31e-23: 104: 12.36
+	Hs
		903209 CUL4B_HUMAN (1-913): 0: 1184: 100.00		WDR5_HUMAN (519-664): 4.67e-21: 96.8: 12.25
+	Hs
		1043441 CUL4B_HUMAN (1-913): 0: 1184: 100.00		WDR5B_HUMAN (536-664): 1.93e-19: 91.8: 15.39
+	Hs
		152876 CUL4B_HUMAN (1-913): 0: 1184: 100.00		APAF_HUMAN (519-649): 1.37e-16: 86.4: 16.42
+	Hs
		1016274 CUL4B_HUMAN (1-913): 0: 1184: 100.00		TBL3_HUMAN (239-675): 4.54e-13: 74.8: 6.36
+	Hs
		1043509 CUL4B_HUMAN (1-913): 0: 1184: 100.00		SNR40_HUMAN (5-71): 6.38e-13: 72.5: 22.39
+	Hs
		1043517 CUL4B_HUMAN (1-913): 0: 1184: 100.00		DCAF5_HUMAN (526-623): 2.4e-10: 66: 31.25
+	Hs
		1043032 CUL4A_HUMAN (161-913): 0: 955: 81.83		DCAF6_HUMAN (479-669): 8.52e-41: 161: 29.85
+	Hs
		473596 CUL4A_HUMAN (161-913): 0: 955: 81.83		DC8L2_HUMAN (237-677): 5.12e-36: 145: 16.74
+	Mm
		1111816 CUL4A_MOUSE (161-913): 0: 966: 81.96		DCAF8_MOUSE (511-677): 2.25e-31: 131: 29.15
+	Hs
		863425 CUL4A_HUMAN (161-913): 0: 955: 81.83		COPA_HUMAN (261-665): 6.18e-29: 125: 10.07
+	Hs
		792982 CUL4A_HUMAN (161-913): 0: 955: 81.83		LIS1_HUMAN (486-675): 1.15e-24: 109: 11.00
+	Hs
		903208 CUL4A_HUMAN (161-913): 0: 955: 81.83		WDR5_HUMAN (519-664): 4.67e-21: 96.8: 12.25