HitPredict

Interactor 1: CUL4B (Q13620)
Cullin-4B (CUL-4B)
Gene: CUL4B

Interactor 2: CRBN (Q96SW2)
Protein cereblon
Gene: CRBN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.747

Property	Details
Experiments	27142104, 27294876, 28514442, 24292625, 33961781, 31973889, 21145461
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0031464 - Cul4A-RING E3 ubiquitin ligase complex
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 913 Hs			1 442
+	Hs
		1043178 CUL4A_HUMAN (161-913): 0: 955: 81.83		CRBN_HUMAN (1-442): 0: 772: 100.00
+	Hs
		1041157 CUL1_HUMAN (213-913): 0: 778: 30.16		CRBN_HUMAN (1-442): 0: 772: 100.00