HitPredict

Interactor 1: ASPP2 (Q13625)
Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)
Gene: TP53BP2

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	38280479, 21189257
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042803 - protein homodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1128 Hs			1 400
+	Hs
		808586 ASPP2_HUMAN (1-1128): 0: 599: 100.00		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		1043731 ASPP2_HUMAN (1-1128): 0: 599: 100.00		ITCH_HUMAN (37-356): 2.6e-60: 211: 14.83
+	Hs
		1296373 ASPP1_HUMAN (1-1128): 4.45e-135: 439: 45.38		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Hs
		125441 ASPP2_HUMAN (1-1128): 0: 599: 100.00		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Hs
		808118 ASPP2_HUMAN (1-1128): 0: 599: 100.00		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00
+	Hs
		125654 ASPP1_HUMAN (1-1128): 4.45e-135: 439: 45.38		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Hs
		808103 Q05BL1_HUMAN (90-1128): 2.47e-152: 484: 99.90		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00
+	Hs
		518833 TPR_HUMAN (62-894): 9.75e-55: 211: 13.79		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		1219842 ANKH1_HUMAN (922-1013): 2.42e-20: 100: 30.44		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Hs
		862101 DAPK1_HUMAN (791-1011): 1.31e-20: 100: 13.12		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Hs
		276153 PSD10_HUMAN (988-1128): 3e-43: 159: 16.77		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		161448 MYPT1_HUMAN (957-1059): 1.81e-16: 87.2: 36.89		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Dm
		1376443 Q9W2J2_DROME (126-1123): 2.51e-75: 272: 27.13		Q9W2L2_DROME (11-209): 8.85e-41: 156: 17.59
+	Mm
		966330 NOTC1_MOUSE (608-1051): 1.86e-45: 182: 14.09		ITCH_MOUSE (119-356): 8.31e-59: 207: 15.66
+	Hs
		161328 MYPT1_HUMAN (957-1059): 1.81e-16: 87.2: 36.89		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		125054 PSD10_HUMAN (988-1128): 3e-43: 159: 16.77		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Hs
		808779 KMT2C_HUMAN (222-886): 1.84e-09: 64.7: 11.45		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		125583 ANR44_HUMAN (962-1128): 1.48e-36: 151: 19.16		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Hs
		1336115 ANR50_HUMAN (836-995): 6.95e-17: 88.7: 16.88		SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62
+	Hs
		1336100 DAPLE_HUMAN (33-349): 6.45e-16: 85.6: 16.36		SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62