HitPredict

Interactor 1: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Interactor 2: NONO (Q15233)
Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)
Gene: NONO

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	36950384
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0007623 - circadian rhythm GO:0016607 - nuclear speck
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 763 Hs			1 471
+	Hs
		1031320 DYR1A_HUMAN (1-763): 0: 613: 100.00		PABP4_HUMAN (66-467): 1.55e-70: 237: 15.42
+	Hs
		1043997 DYR1A_HUMAN (1-763): 0: 613: 100.00		PSPC1_HUMAN (20-470): 2.17e-67: 226: 58.41
+	Hs
		516508 DYR1A_HUMAN (1-763): 0: 613: 100.00		PABP1_HUMAN (66-459): 7.11e-65: 222: 14.89
+	Hs
		642764 DYR1A_HUMAN (1-763): 0: 613: 100.00		ELAV4_HUMAN (40-205): 3.53e-60: 203: 28.02
+	Hs
		613447 DYR1A_HUMAN (1-763): 0: 613: 100.00		SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92
+	Hs
		1043793 DYR1A_HUMAN (1-763): 0: 613: 100.00		ELAV3_HUMAN (54-270): 2.36e-48: 171: 22.46
+	Hs
		1043817 DYR1A_HUMAN (1-763): 0: 613: 100.00		ELAV1_HUMAN (68-205): 7.38e-47: 166: 27.82
+	Hs
		1020254 DYR1A_HUMAN (1-763): 0: 613: 100.00		ELAV2_HUMAN (150-210): 9.69e-14: 74.5: 25.81
+	Hs
		1044115 DYR1A_HUMAN (1-763): 0: 613: 100.00		RBM4_HUMAN (75-182): 7.64e-09: 59.3: 35.71
+	Hs
		414927 CDK1_HUMAN (156-482): 1.29e-121: 368: 26.57		NONO_HUMAN (1-471): 1.15e-97: 303: 100.00
+	Hs
		516362 CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85		PABP1_HUMAN (66-459): 7.11e-65: 222: 14.89
+	Hs
		613336 CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85		SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92
+	Hs
		414931 CDK1_HUMAN (156-482): 1.29e-121: 368: 26.57		ELAV1_HUMAN (68-205): 7.38e-47: 166: 27.82
+	Hs
		681862 AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42		ELAV1_HUMAN (68-205): 7.38e-47: 166: 27.82
+	Sc
		376610 YAK1_YEAST (19-586): 3.53e-116: 371: 29.05		PABP_YEAST (30-384): 3.77e-37: 145: 16.50
+	Hs
		625400 CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85		ELAV2_HUMAN (150-210): 9.69e-14: 74.5: 25.81
+	Hs
		625590 CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85		RBM4_HUMAN (75-182): 7.64e-09: 59.3: 35.71