HitPredict

Interactor 1: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Interactor 2: SRSF7 (Q16629)
Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)
Gene: SRSF7

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	30773093, 36950384
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016607 - nuclear speck GO:0048025 - negative regulation of mRNA splicing, via spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 763 Hs			1 238
+	Hs
		1043996 DYR1A_HUMAN (1-763): 0: 613: 100.00		SRS12_HUMAN (1-218): 8.5e-28: 108: 32.60
+	Hs
		853885 DYR1A_HUMAN (1-763): 0: 613: 100.00		NCBP2_HUMAN (10-114): 8.08e-26: 100: 23.42
+	Hs
		432699 DYR1A_HUMAN (1-763): 0: 613: 100.00		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		951958 DYR1A_HUMAN (1-763): 0: 613: 100.00		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		1031320 DYR1A_HUMAN (1-763): 0: 613: 100.00		PABP4_HUMAN (1-95): 5.76e-21: 92.9: 27.00
+	Hs
		992764 DYR1A_HUMAN (1-763): 0: 613: 100.00		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Hs
		516508 DYR1A_HUMAN (1-763): 0: 613: 100.00		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11
+	Hs
		1044115 DYR1A_HUMAN (1-763): 0: 613: 100.00		RBM4_HUMAN (12-89): 4.44e-14: 72.2: 33.33
+	Hs
		853953 DYRK2_HUMAN (46-549): 5.03e-120: 375: 33.53		NCBP2_HUMAN (10-114): 8.08e-26: 100: 23.42
+	Hs
		625466 CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85		SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00
+	Hs
		432550 CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Sc
		376610 YAK1_YEAST (19-586): 3.53e-116: 371: 29.05		PABP_YEAST (7-95): 4.44e-17: 81.7: 22.34
+	Zm
		11850 A0A1D6FHK3_MAIZE (103-525): 7.64e-118: 362: 22.50		A0A1D6II08_MAIZE (7-214): 2.53e-18: 85.1: 13.55
+	Hs
		516362 CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11
+	Hs
		625590 CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85		RBM4_HUMAN (12-89): 4.44e-14: 72.2: 33.33
+	At
		51039 A1L4Y9_ARATH (129-483): 3.59e-56: 199: 32.90		RSZ33_ARATH (1-229): 5.07e-28: 109: 34.18
+	At
		847177 AFC3_ARATH (129-483): 3.59e-56: 199: 32.90		RSZ33_ARATH (1-229): 5.07e-28: 109: 34.18
+	At
		286430 AFC3_ARATH (129-483): 3.59e-56: 199: 32.90		RSZ21_ARATH (11-212): 1.3e-26: 103: 37.13
+	At
		51041 A1L4Y9_ARATH (129-483): 3.59e-56: 199: 32.90		RZ22A_ARATH (11-192): 6.24e-24: 96.5: 33.33
+	At
		847179 AFC3_ARATH (129-483): 3.59e-56: 199: 32.90		RZ22A_ARATH (11-192): 6.24e-24: 96.5: 33.33