HitPredict

Interactor 1: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Interactor 2: SPRE1 (Q7Z699)
Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1)
Gene: SPRED1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	35914814
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 763 Hs			1 444
+	Hs
		1043917 DYR1A_HUMAN (1-763): 0: 613: 100.00		SPRE2_HUMAN (1-444): 1.36e-148: 430: 50.44
+	Hs
		840471 DYR1A_HUMAN (1-763): 0: 613: 100.00		VASP_HUMAN (10-338): 1.37e-64: 214: 19.36
+	Hs
		208134 DYR1A_HUMAN (1-763): 0: 613: 100.00		SPY2_HUMAN (169-433): 5.08e-63: 208: 16.61
+	Hs
		1043956 DYR1A_HUMAN (1-763): 0: 613: 100.00		ENAH_HUMAN (10-153): 1.2e-55: 195: 28.28
+	Hs
		1237906 DYR1B_HUMAN (57-600): 2.33e-137: 421: 68.13		ENAH_HUMAN (10-153): 1.2e-55: 195: 28.28
+	Hs
		681745 AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42		VASP_HUMAN (10-338): 1.37e-64: 214: 19.36