HitPredict

Interactor 1: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Interactor 2: PSPC1 (Q8WXF1)
Paraspeckle component 1 (Paraspeckle protein 1)
Gene: PSPC1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	36950384
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 763 Hs			1 523
+	Hs
		516508 DYR1A_HUMAN (1-763): 0: 613: 100.00		PABP1_HUMAN (4-522): 4.65e-70: 237: 14.16
+	Hs
		1043809 DYR1A_HUMAN (1-763): 0: 613: 100.00		NONO_HUMAN (50-523): 4.22e-68: 228: 57.60
+	Hs
		613447 DYR1A_HUMAN (1-763): 0: 613: 100.00		SFPQ_HUMAN (53-523): 3.05e-59: 210: 54.14
+	Hs
		1031320 DYR1A_HUMAN (1-763): 0: 613: 100.00		PABP4_HUMAN (3-149): 2.52e-27: 118: 18.83
+	Hs
		642764 DYR1A_HUMAN (1-763): 0: 613: 100.00		ELAV4_HUMAN (41-156): 2.45e-16: 82.6: 32.79
+	Hs
		1020254 DYR1A_HUMAN (1-763): 0: 613: 100.00		ELAV2_HUMAN (84-156): 1.29e-13: 74.1: 31.65
+	Hs
		1043817 DYR1A_HUMAN (1-763): 0: 613: 100.00		ELAV1_HUMAN (84-156): 3.1e-13: 72.6: 29.11
+	Hs
		1043793 DYR1A_HUMAN (1-763): 0: 613: 100.00		ELAV3_HUMAN (84-151): 6.6e-13: 72.2: 32.43
+	Hs
		1044115 DYR1A_HUMAN (1-763): 0: 613: 100.00		RBM4_HUMAN (83-190): 4.98e-09: 60.1: 32.14
+	Hs
		414927 CDK1_HUMAN (156-482): 1.29e-121: 368: 26.57		NONO_HUMAN (50-523): 4.22e-68: 228: 57.60
+	Hs
		516362 CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85		PABP1_HUMAN (4-522): 4.65e-70: 237: 14.16
+	Hs
		613336 CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85		SFPQ_HUMAN (53-523): 3.05e-59: 210: 54.14
+	Sc
		376610 YAK1_YEAST (19-586): 3.53e-116: 371: 29.05		PABP_YEAST (4-373): 1.42e-48: 178: 14.85
+	Hs
		414931 CDK1_HUMAN (156-482): 1.29e-121: 368: 26.57		ELAV1_HUMAN (84-156): 3.1e-13: 72.6: 29.11
+	Hs
		681862 AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42		ELAV1_HUMAN (84-156): 3.1e-13: 72.6: 29.11
+	Hs
		625400 CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85		ELAV2_HUMAN (84-156): 1.29e-13: 74.1: 31.65
+	Hs
		625590 CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85		RBM4_HUMAN (83-190): 4.98e-09: 60.1: 32.14