HitPredict

Interactor 1: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Interactor 2: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.672

Property	Details
Experiments	28561026, 30773093, 31024071, 36950384
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 763 Hs			1 1164
+	Mm
		1142388 DYR1A_MOUSE (1-763): 0: 610: 99.21		TSC1_MOUSE (1-1164): 0: 695: 86.98
+	Hs
		415012 CDK1_HUMAN (156-482): 1.29e-121: 368: 26.57		TSC1_HUMAN (1-1164): 0: 725: 100.00
+	Hs
		681956 AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42		TSC1_HUMAN (1-1164): 0: 725: 100.00
+	Mm
		682126 AKT1_MOUSE (38-466): 2.26e-117: 364: 19.42		TSC1_MOUSE (1-1164): 0: 695: 86.98
+	Hs
		728476 DYR1A_HUMAN (1-763): 0: 613: 100.00		MYH11_HUMAN (392-1122): 2.73e-28: 126: 8.64
+	Hs
		148781 DYR1A_HUMAN (1-763): 0: 613: 100.00		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		528372 DYR1A_HUMAN (1-763): 0: 613: 100.00		MYH6_HUMAN (623-1102): 9.65e-21: 101: 14.55
+	Hs
		725159 DYR1A_HUMAN (1-763): 0: 613: 100.00		MYH10_HUMAN (687-992): 3.26e-09: 63.6: 20.43
+	Hs
		681840 AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42		DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33
+	Hs
		148173 DYRK3_HUMAN (7-531): 1.12e-117: 368: 30.64		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		148286 CDK1_HUMAN (156-482): 1.29e-121: 368: 26.57		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		681696 AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		414713 CDK1_HUMAN (156-482): 1.29e-121: 368: 26.57		DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54
+	Hs
		551616 AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42		DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54
+	Hs
		522542 CDK3_HUMAN (156-436): 1.81e-117: 358: 26.12		MYH1_HUMAN (393-967): 5.76e-21: 102: 11.23
+	Hs
		528368 CDK3_HUMAN (156-436): 1.81e-117: 358: 26.12		MYH6_HUMAN (623-1102): 9.65e-21: 101: 14.55
+	Hs
		960128 CDK3_HUMAN (156-436): 1.81e-117: 358: 26.12		MYH2_HUMAN (393-980): 6.89e-21: 101: 11.32
+	Hs
		522604 CDK3_HUMAN (156-436): 1.81e-117: 358: 26.12		MYH7_HUMAN (391-922): 3.39e-17: 89.9: 8.59
+	Hs
		528405 CDK3_HUMAN (156-436): 1.81e-117: 358: 26.12		MYH8_HUMAN (822-1163): 6.53e-11: 69.1: 10.73
+	Hs
		502908 CDK3_HUMAN (156-436): 1.81e-117: 358: 26.12		MYH3_HUMAN (400-850): 1.77e-10: 67.9: 10.00