HitPredict

Interactor 1: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Interactor 2: SORL (Q92673)
Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)
Gene: SORL1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.80	0.514

Property	Details
Experiments	36950384
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Pkinase~fn3
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 763 Hs			1 2214
+	Hs
		213902 DYRK3_HUMAN (7-531): 1.12e-117: 368: 30.64		SORL_HUMAN (1-2214): 0: 1927: 100.00
+	Hs
		415035 CDK1_HUMAN (156-482): 1.29e-121: 368: 26.57		SORT_HUMAN (60-756): 7.38e-180: 572: 28.88
+	Hs
		625572 CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85		SORT_HUMAN (60-756): 7.38e-180: 572: 28.88
+	Hs
		1031979 DYR1A_HUMAN (1-763): 0: 613: 100.00		PTPRS_HUMAN (1571-2022): 3.54e-53: 209: 19.15
+	Hs
		957519 DYR1A_HUMAN (1-763): 0: 613: 100.00		VLDLR_HUMAN (1457-1575): 6.38e-21: 102: 28.57
+	Hs
		254260 DYR1A_HUMAN (1-763): 0: 613: 100.00		LRP4_HUMAN (1350-1709): 2.47e-19: 98.1: 15.51
+	Hs
		957603 DYR1A_HUMAN (1-763): 0: 613: 100.00		LRP2_HUMAN (1316-1712): 1.36e-18: 95.8: 17.49
+	Hs
		1044211 DYR1A_HUMAN (1-763): 0: 613: 100.00		LRP1B_HUMAN (1311-1577): 6.86e-10: 66.9: 10.37
+	Dm
		957596 Q9VX06_DROME (73-489): 9.89e-125: 400: 81.58		YL_DROME (1411-1697): 5.78e-09: 63.9: 13.24
+	Dm
		830212 MNB_DROME (73-489): 1.84e-123: 393: 81.58		YL_DROME (1411-1697): 5.78e-09: 63.9: 13.24