HitPredict

Interactor 1: PTC1 (Q13635)
Protein patched homolog 1 (PTC) (PTC1)
Gene: PTCH1

Interactor 2: SHH (Q15465)
Sonic hedgehog protein (SHH) (EC 3.1.-.-) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
Gene: SHH

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.924

The method score is based on:

Property Details
Experiments 16282375, 19561609, 29954986, 30139912, 29995851
Identification Methods pull down, nuclear magnetic resonance, 3D electron microscopy, anti tag coimmunoprecipitation, molecular sieving
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains HH_signal~Patched
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001658 - branching involved in ureteric bud morphogenesis
GO:0005113 - patched binding
GO:0005886 - plasma membrane
GO:0007224 - smoothened signaling pathway
and 10 others

more...
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 1447
Hs

1 462
+ Mm
+ Dm
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024