HitPredict

Interactor 1: PTC1 (Q13635)
Protein patched homolog 1 (PTC) (PTC1)
Gene: PTCH1

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	25092867
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1447 Hs			1 975
+	Hs
		1044434 PTC1_HUMAN (1-1447): 0: 1579: 100.00		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		1044412 PTC1_HUMAN (1-1447): 0: 1579: 100.00		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		808120 PTC1_HUMAN (1-1447): 0: 1579: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125442 PTC1_HUMAN (1-1447): 0: 1579: 100.00		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Dm
		577405 PTC_DROME (48-1283): 0: 993: 38.23		NEDD4_DROME (6-975): 0: 845: 46.15
+	Hs
		168007 NPC1_HUMAN (59-1191): 0: 713: 19.74		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Dm
		577424 PTC_DROME (48-1283): 0: 993: 38.23		SUDX_DROME (20-971): 0: 747: 32.47
+	Hs
		1044442 PTC1_HUMAN (1-1447): 0: 1579: 100.00		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		1044440 PTC1_HUMAN (1-1447): 0: 1579: 100.00		SMUF2_HUMAN (21-324): 2e-29: 127: 22.56
+	Dm
		577378 PTC_DROME (48-1283): 0: 993: 38.23		SMUF1_DROME (19-971): 0: 618: 27.01
+	Dm
		577410 PTC_DROME (48-1283): 0: 993: 38.23		Q9VXR3_DROME (554-971): 4.42e-157: 516: 40.33
+	Hs
		168027 NPC1_HUMAN (59-1191): 0: 713: 19.74		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		167863 NPC1_HUMAN (59-1191): 0: 713: 19.74		NEDD4_HUMAN (94-975): 0: 724: 49.78