HitPredict

Interactor 1: FHL1 (Q13642)
Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM-protein 1) (SLIM) (SLIM-1)
Gene: FHL1

Interactor 2: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	19139564
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030154 - cell differentiation GO:0046872 - metal ion binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 323 Hs			1 467
+	Hs
		950172 FHL1_HUMAN (1-323): 7.74e-90: 272: 100.00		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		1078700 ZN510_HUMAN (29-292): 1.12e-48: 174: 11.77		SMAD2_HUMAN (1-467): 0: 675: 100.00
+	Hs
		1078754 ZN251_HUMAN (22-317): 8.15e-88: 278: 11.96		SMAD1_HUMAN (1-467): 0: 565: 55.53
+	Hs
		200171 TGFI1_HUMAN (37-246): 3.97e-61: 203: 29.25		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Mm
		1143672 TGFI1_MOUSE (101-250): 2.6e-40: 148: 29.61		SMAD3_MOUSE (1-467): 0: 617: 83.94
+	Hs
		1044596 FHL3_HUMAN (3-92): 3.86e-17: 81.9: 33.70		SMAD2_HUMAN (1-467): 0: 675: 100.00
+	Hs
		1050645 FHL2_HUMAN (3-92): 4.15e-15: 76.2: 34.78		SMAD2_HUMAN (1-467): 0: 675: 100.00
+	Hs
		1078780 ZN510_HUMAN (29-292): 1.12e-48: 174: 11.77		SMAD1_HUMAN (1-467): 0: 565: 55.53
+	Hs
		1035425 FHL1_HUMAN (1-323): 7.74e-90: 272: 100.00		SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58
+	Hs
		950173 FHL3_HUMAN (3-92): 3.86e-17: 81.9: 33.70		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		950180 FHL2_HUMAN (3-92): 4.15e-15: 76.2: 34.78		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		950213 ZN329_HUMAN (163-318): 1.71e-12: 69.8: 8.92		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		200176 TGFI1_HUMAN (37-246): 3.97e-61: 203: 29.25		SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58
+	Hs
		1035638 ZN510_HUMAN (29-292): 1.12e-48: 174: 11.77		SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58
+	Hs
		167310 TGFI1_HUMAN (37-246): 3.97e-61: 203: 29.25		SMAD7_HUMAN (13-443): 2.55e-109: 331: 25.23
+	Hs
		1035426 FHL3_HUMAN (3-92): 3.86e-17: 81.9: 33.70		SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58
+	Hs
		1035432 FHL2_HUMAN (3-92): 4.15e-15: 76.2: 34.78		SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58