HitPredict

Interactor 1: FHL3 (Q13643)
Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle LIM-protein 2) (SLIM-2)
Gene: FHL3

Interactor 2: ZYX (Q15942)
Zyxin (Zyxin-2)
Gene: ZYX

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LIM~LIM
Common GO terms	GO:0001725 - stress fiber GO:0005634 - nucleus GO:0005925 - focal adhesion GO:0046872 - metal ion binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 280 Hs			1 572
+	Hs
		823405 PAXI_HUMAN (3-218): 4.3e-73: 236: 28.70		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		1044595 FHL3_HUMAN (1-280): 8.02e-79: 241: 100.00		TRIP6_HUMAN (63-571): 6e-66: 224: 32.82
+	Hs
		823508 PAXI_HUMAN (3-218): 4.3e-73: 236: 28.70		LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80
+	Hs
		823403 PAXI_HUMAN (3-218): 4.3e-73: 236: 28.70		TRIP6_HUMAN (63-571): 6e-66: 224: 32.82
+	Hs
		1080752 PDLI5_HUMAN (3-155): 6.13e-48: 169: 28.76		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		238967 LPXN_HUMAN (98-278): 6.74e-49: 168: 30.39		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		238998 LPXN_HUMAN (98-278): 6.74e-49: 168: 30.39		LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80
+	Hs
		238966 LPXN_HUMAN (98-278): 6.74e-49: 168: 30.39		TRIP6_HUMAN (63-571): 6e-66: 224: 32.82
+	Hs
		823353 PAXI_HUMAN (3-218): 4.3e-73: 236: 28.70		PAXI_HUMAN (8-500): 3.72e-32: 132: 12.12
+	Hs
		1044729 FHL3_HUMAN (1-280): 8.02e-79: 241: 100.00		TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28
+	Hs
		1044590 FHL3_HUMAN (1-280): 8.02e-79: 241: 100.00		FHL2_HUMAN (468-572): 2.68e-19: 90.1: 21.91
+	Hs
		200190 TGFI1_HUMAN (3-218): 5.41e-68: 219: 27.32		TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28
+	Hs
		1044587 FHL3_HUMAN (1-280): 8.02e-79: 241: 100.00		FHL3_HUMAN (410-544): 1.63e-09: 61.2: 28.99
+	Hs
		816231 PAXI_HUMAN (3-218): 4.3e-73: 236: 28.70		LIMS1_HUMAN (383-566): 1.09e-10: 65.1: 25.95
+	Hs
		200167 PAXI_HUMAN (3-218): 4.3e-73: 236: 28.70		TGFI1_HUMAN (377-441): 9.8e-10: 63: 32.31
+	Hs
		1293409 PDLI5_HUMAN (3-155): 6.13e-48: 169: 28.76		TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28
+	Hs
		238982 LPXN_HUMAN (98-278): 6.74e-49: 168: 30.39		LPP_HUMAN (4-495): 1.9e-13: 75.1: 13.92
+	Hs
		238953 LPXN_HUMAN (98-278): 6.74e-49: 168: 30.39		LIMS1_HUMAN (383-566): 1.09e-10: 65.1: 25.95