HitPredict

Interactor 1: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Interactor 2: MARE1 (Q15691)
Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1)
Gene: MAPRE1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	26496610, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CH~EF-hand_7, CH~EFhand_Ca_insen, CH~Spectrin
Common GO terms	GO:0005829 - cytosol GO:0045296 - cadherin binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 2472 Hs			1 268
+	Hs
		1045564 SPTN1_HUMAN (1-2472): 0: 714: 100.00		MARE3_HUMAN (1-268): 1.91e-134: 382: 63.70
+	Hs
		297830 K0754_HUMAN (1-1482): 9.32e-58: 225: 14.65		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Hs
		963333 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Hs
		974082 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Hs
		166713 CE290_HUMAN (808-2443): 1.12e-32: 142: 10.61		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Hs
		1068538 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Hs
		3527 A0A0U1RQJ2_HUMAN (10-649): 1.32e-27: 125: 17.25		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Hs
		974173 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		MARE3_HUMAN (1-268): 1.91e-134: 382: 63.70
+	Hs
		1077170 MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Mm
		1142238 MACF1_MOUSE (946-2364): 9.74e-13: 76.6: 10.17		MARE1_MOUSE (1-257): 1.2e-149: 420: 96.89
+	Hs
		521551 ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Dm
		54305 A1Z9J2_DROME (1-736): 1.22e-28: 129: 17.12		Q9XZ57_DROME (1-265): 4e-126: 361: 52.60
+	Hs
		1077108 CP250_HUMAN (1768-2439): 4.39e-10: 67.7: 8.94		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Hs
		211586 ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Hs
		1357665 MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48		MARE3_HUMAN (1-268): 1.91e-134: 382: 63.70
+	Hs
		828641 CENPF_HUMAN (1723-2444): 8.12e-13: 77: 9.28		MARE3_HUMAN (1-268): 1.91e-134: 382: 63.70