HitPredict

Interactor 1: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Interactor 2: FGD5 (Q6ZNL6)
FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23)
Gene: FGD5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	33762435
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1, RhoGEF~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2472 Hs			1 1462
+	Hs
		974098 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		FGD5_HUMAN (1-1462): 0: 1231: 100.00
+	Hs
		1068579 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		FGD5_HUMAN (1-1462): 0: 1231: 100.00
+	Hs
		1045423 SPTN1_HUMAN (1-2472): 0: 714: 100.00		ITSN1_HUMAN (486-1262): 3.75e-81: 297: 13.48
+	Mm
		57827 SPTN1_MOUSE (1-2472): 0: 712: 98.42		KALRN_MOUSE (839-1450): 2.8e-72: 270: 15.36
+	Hs
		224714 SPTN1_HUMAN (1-2472): 0: 714: 100.00		KALRN_HUMAN (839-1450): 2.09e-70: 264: 15.65
+	Mm
		57809 B9EKJ1_MOUSE (1-2472): 0: 706: 98.18		KALRN_MOUSE (839-1450): 2.8e-72: 270: 15.36
+	Hs
		1045521 SPTN1_HUMAN (1-2472): 0: 714: 100.00		ECT2_HUMAN (887-1207): 1.07e-70: 258: 19.94
+	Hs
		1045445 SPTN1_HUMAN (1-2472): 0: 714: 100.00		ZFY16_HUMAN (1229-1385): 1.41e-11: 71.6: 30.82
+	Hs
		1068638 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		FGD4_HUMAN (703-1459): 6.54e-142: 455: 22.61
+	Mm
		57856 Q68FG2_MOUSE (141-1932): 3.76e-63: 242: 20.06		KALRN_MOUSE (839-1450): 2.8e-72: 270: 15.36
+	Hs
		164666 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		ECT2_HUMAN (887-1207): 1.07e-70: 258: 19.94
+	Hs
		963335 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		ITSN1_HUMAN (486-1262): 3.75e-81: 297: 13.48
+	Hs
		1068630 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		Q96D37_HUMAN (828-1452): 6.85e-95: 326: 14.29
+	Hs
		548710 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		VAV_HUMAN (828-1452): 2.24e-94: 326: 14.29
+	Hs
		1059285 GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57		ITSN2_HUMAN (529-1237): 4.9e-81: 297: 12.44
+	Hs
		974083 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		ITSN1_HUMAN (486-1262): 3.75e-81: 297: 13.48
+	Hs
		974160 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		ITSN2_HUMAN (529-1237): 4.9e-81: 297: 12.44
+	Mm
		57815 F6Q750_MOUSE (1-2274): 9.95e-40: 165: 11.20		KALRN_MOUSE (839-1450): 2.8e-72: 270: 15.36
+	Hs
		963418 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		ECT2_HUMAN (887-1207): 1.07e-70: 258: 19.94
+	Hs
		974147 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		ECT2_HUMAN (887-1207): 1.07e-70: 258: 19.94