HitPredict

Interactor 1: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Interactor 2: MY18A (Q92614)
Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210)
Gene: MYO18A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EF-hand_7~Myosin_head, Myosin_head~Spectrin
Common GO terms	GO:0016020 - membrane GO:0051015 - actin filament binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2472 Hs			1 2054
+	Hs
		164647 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Hs
		963381 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Hs
		974117 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Hs
		1068617 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Hs
		211632 ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Hs
		724817 SPTN1_HUMAN (1-2472): 0: 714: 100.00		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		522612 SPTN1_HUMAN (1-2472): 0: 714: 100.00		MYH7_HUMAN (954-1819): 2.95e-41: 169: 12.80
+	Hs
		1045537 SPTN1_HUMAN (1-2472): 0: 714: 100.00		MYO5C_HUMAN (1119-1615): 4.36e-24: 113: 12.21
+	Hs
		164575 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Dm
		404218 ACTN_DROME (1864-2470): 1.19e-77: 281: 30.27		MYSA_DROME (1659-2054): 1.99e-22: 108: 12.50
+	Hs
		724781 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		724786 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		724839 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		963431 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		MYO5C_HUMAN (1119-1615): 4.36e-24: 113: 12.21
+	Hs
		1068591 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		MY18B_HUMAN (1024-1700): 3.43e-34: 146: 11.13
+	Hs
		110636 H3BPE1_HUMAN (9-1261): 4.01e-18: 94.7: 12.35		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		725073 MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		521484 ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		724994 CP250_HUMAN (1768-2439): 4.39e-10: 67.7: 8.94		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		211515 ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96