HitPredict

Interactor 1: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Interactor 2: CEP63 (Q96MT8)
Centrosomal protein of 63 kDa (Cep63)
Gene: CEP63

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.641

Property	Details
Experiments	17043677, unassigned1973, 35709258
Identification Methods	two hybrid, two hybrid fragment pooling approach, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2472 Hs			1 703
+	Hs
		724817 SPTN1_HUMAN (1-2472): 0: 714: 100.00		MYH9_HUMAN (1-520): 3.09e-20: 98.3: 12.02
+	Hs
		148786 SPTN1_HUMAN (1-2472): 0: 714: 100.00		CTRO_HUMAN (22-572): 2.81e-16: 85.5: 13.29
+	Hs
		1045471 SPTN1_HUMAN (1-2472): 0: 714: 100.00		MY18A_HUMAN (51-572): 5.91e-15: 81.2: 16.15
+	Hs
		522612 SPTN1_HUMAN (1-2472): 0: 714: 100.00		MYH7_HUMAN (367-695): 1.25e-09: 64: 10.00
+	Mm
		93541 SPTA1_MOUSE (1-2472): 2.17e-161: 558: 54.20		DESP_MOUSE (59-550): 4.18e-09: 62.5: 18.91
+	Hs
		360660 SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81		CP250_HUMAN (150-696): 7.75e-10: 64.8: 11.94
+	Hs
		164656 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		CEP63_HUMAN (1-703): 1.84e-64: 228: 100.00
+	Hs
		963396 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		CEP63_HUMAN (1-703): 1.84e-64: 228: 100.00
+	Hs
		974132 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		CEP63_HUMAN (1-703): 1.84e-64: 228: 100.00
+	Dm
		404218 ACTN_DROME (1864-2470): 1.19e-77: 281: 30.27		MYSA_DROME (1-419): 8.7e-13: 74.2: 14.45
+	Hs
		164575 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		MYH9_HUMAN (1-520): 3.09e-20: 98.3: 12.02
+	Hs
		148142 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		CTRO_HUMAN (22-572): 2.81e-16: 85.5: 13.29
+	Hs
		164647 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		MY18A_HUMAN (51-572): 5.91e-15: 81.2: 16.15
+	Hs
		724781 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		MYH9_HUMAN (1-520): 3.09e-20: 98.3: 12.02
+	Hs
		148690 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		CTRO_HUMAN (22-572): 2.81e-16: 85.5: 13.29
+	Hs
		963381 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		MY18A_HUMAN (51-572): 5.91e-15: 81.2: 16.15
+	Hs
		724786 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		MYH9_HUMAN (1-520): 3.09e-20: 98.3: 12.02
+	Hs
		974117 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		MY18A_HUMAN (51-572): 5.91e-15: 81.2: 16.15
+	Mm
		93578 PLEC_MOUSE (1-1250): 7.03e-38: 159: 10.80		DESP_MOUSE (59-550): 4.18e-09: 62.5: 18.91
+	Hs
		974137 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		CP250_HUMAN (150-696): 7.75e-10: 64.8: 11.94