HitPredict

Interactor 1: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Interactor 2: TES (Q9UGI8)
Testin (TESS)
Gene: TES

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	15656790, 28378594
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030054 - cell junction GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2472 Hs			1 421
+	Hs
		1045539 SPTN1_HUMAN (1-2472): 0: 714: 100.00		PDLI7_HUMAN (358-421): 2.61e-09: 61: 26.56
+	Ce
		68944 G4S034_CAEEL (4-2472): 4.08e-165: 570: 57.91		A8WFL0_CAEEL (231-415): 3.19e-57: 194: 39.79
+	Ce
		103419 G4S034_CAEEL (4-2472): 4.08e-165: 570: 57.91		G5EFG1_CAEEL (301-420): 2.29e-26: 113: 22.13
+	Hs
		963447 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		TES_HUMAN (1-421): 2.51e-143: 416: 100.00
+	Hs
		1068693 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		TES_HUMAN (1-421): 2.51e-143: 416: 100.00
+	Hs
		1355078 MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48		TES_HUMAN (1-421): 2.51e-143: 416: 100.00
+	Hs
		521634 ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25		TES_HUMAN (1-421): 2.51e-143: 416: 100.00
+	Dm
		54833 ACTN_DROME (1864-2470): 1.19e-77: 281: 30.27		ZASP_DROME (215-295): 1.95e-09: 62.1: 23.46
+	Mm
		1337461 ACTN2_MOUSE (1843-2210): 5.15e-13: 77: 23.23		LDB3_MOUSE (84-418): 4.16e-81: 265: 17.80
+	Hs
		254383 ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25		LDB3_HUMAN (84-417): 3.94e-82: 268: 17.56
+	Hs
		823397 GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57		PAXI_HUMAN (298-421): 1.67e-35: 139: 22.58
+	Ce
		104744 G5EC35_CAEEL (2-1107): 2.57e-41: 170: 17.91		G5EFG1_CAEEL (301-420): 2.29e-26: 113: 22.13
+	Hs
		963432 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		PDLI7_HUMAN (358-421): 2.61e-09: 61: 26.56
+	Hs
		823516 MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48		PAXI_HUMAN (298-421): 1.67e-35: 139: 22.58
+	Hs
		1068675 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		PDLI7_HUMAN (358-421): 2.61e-09: 61: 26.56
+	Mm
		1186636 ACTN1_MOUSE (1862-2210): 1.97e-10: 68.6: 21.99		PDLI5_MOUSE (298-420): 1.98e-30: 125: 26.83
+	Gg
		396532 ACTN1_CHICK (1873-2210): 8.79e-12: 73.2: 21.56		ZYX_CHICK (84-361): 1.84e-25: 110: 13.90
+	Hs
		1044584 MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48		FHL1_HUMAN (260-368): 9.45e-11: 64.7: 33.95
+	Hs
		506846 SPTB1_HUMAN (1743-2409): 3.32e-13: 78.1: 19.70		PDLI7_HUMAN (358-421): 2.61e-09: 61: 26.56
+	Hs
		521623 ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25		PDLI7_HUMAN (358-421): 2.61e-09: 61: 26.56