HitPredict

Interactor 1: HNRPD (Q14103)
Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)
Gene: HNRNPD

Interactor 2: ROAA (Q99729)
Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (APOBEC1-binding protein 1) (ABBP-1)
Gene: HNRNPAB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	34349018, 26496610, 26318153, 37071682
Identification Methods	cross-linking study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0010468 - regulation of gene expression GO:0045893 - positive regulation of DNA-templated transcription and 1 others more... GO:1990904 - ribonucleoprotein complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 332
+	Hs
		453351 HNRPD_HUMAN (1-355): 9.1e-72: 229: 100.00		ROA1_HUMAN (58-235): 7.34e-71: 226: 38.38
+	Hs
		161942 HNRDL_HUMAN (89-355): 3.71e-56: 190: 62.63		ROA1_HUMAN (58-235): 7.34e-71: 226: 38.38
+	Hs
		1048054 HNRPD_HUMAN (1-355): 9.1e-72: 229: 100.00		HNRPD_HUMAN (32-332): 1.26e-55: 186: 55.63
+	Hs
		453567 ROAA_HUMAN (30-355): 3.41e-55: 185: 53.89		ROA1_HUMAN (58-235): 7.34e-71: 226: 38.38
+	Hs
		852054 HNRPD_HUMAN (1-355): 9.1e-72: 229: 100.00		ROA3_HUMAN (36-237): 3.44e-53: 180: 36.36
+	Hs
		162127 HNRDL_HUMAN (89-355): 3.71e-56: 190: 62.63		ROAA_HUMAN (1-332): 2.58e-68: 218: 100.00
+	Hs
		162045 HNRPD_HUMAN (1-355): 9.1e-72: 229: 100.00		HNRDL_HUMAN (12-332): 3.27e-51: 176: 49.85
+	Xl
		1193358 Q7ZYE9_XENLA (49-355): 2.29e-58: 193: 57.24		Q7ZYE9_XENLA (1-332): 1.8e-54: 182: 66.27
+	Hs
		609857 HNRPD_HUMAN (1-355): 9.1e-72: 229: 100.00		ROA2_HUMAN (63-246): 1.97e-38: 141: 38.22
+	Hs
		161962 HNRDL_HUMAN (89-355): 3.71e-56: 190: 62.63		ROA2_HUMAN (63-246): 1.97e-38: 141: 38.22
+	Hs
		610017 ROAA_HUMAN (30-355): 3.41e-55: 185: 53.89		ROA2_HUMAN (63-246): 1.97e-38: 141: 38.22
+	Mm
		825781 HNRPD_MOUSE (1-355): 8.17e-72: 229: 95.49		ROA1_MOUSE (24-139): 1.47e-16: 81: 25.00
+	Hs
		1048086 HNRPD_HUMAN (1-355): 9.1e-72: 229: 100.00		RA1L2_HUMAN (24-139): 3.49e-16: 79.8: 25.00
+	Hs
		516511 HNRPD_HUMAN (1-355): 9.1e-72: 229: 100.00		PABP1_HUMAN (144-238): 2.78e-10: 63.3: 15.63
+	Hs
		162063 HNRDL_HUMAN (89-355): 3.71e-56: 190: 62.63		RA1L2_HUMAN (24-139): 3.49e-16: 79.8: 25.00
+	Hs
		162035 HNRDL_HUMAN (89-355): 3.71e-56: 190: 62.63		PABP4_HUMAN (144-238): 3.57e-11: 66: 15.63
+	Hs
		161948 HNRDL_HUMAN (89-355): 3.71e-56: 190: 62.63		PABP1_HUMAN (144-238): 2.78e-10: 63.3: 15.63
+	Hs
		516663 ROAA_HUMAN (30-355): 3.41e-55: 185: 53.89		PABP1_HUMAN (144-238): 2.78e-10: 63.3: 15.63