HitPredict

Interactor 1: HNRPD (Q14103)
Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)
Gene: HNRNPD

Interactor 2: IF2B2 (Q9Y6M1)
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2)
Gene: IGF2BP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	12674497
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0010468 - regulation of gene expression GO:0070934 - CRD-mediated mRNA stabilization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 355 Hs			1 599
+	Hs
		1048259 HNRPD_HUMAN (1-355): 9.1e-72: 229: 100.00		IF2B1_HUMAN (2-599): 2.29e-130: 395: 63.89
+	Hs
		1306051 ROAA_HUMAN (30-355): 3.41e-55: 185: 53.89		IF2B2_HUMAN (1-599): 1.06e-146: 438: 100.00
+	Xl
		251135 Q6GM69_XENLA (27-355): 2.09e-60: 198: 55.99		IF23A_XENLA (2-599): 4.02e-132: 400: 64.55
+	Xl
		251139 EPABA_XENLA (4-284): 2.88e-57: 198: 17.18		IF23A_XENLA (2-599): 4.02e-132: 400: 64.55
+	Hs
		162175 HNRDL_HUMAN (89-355): 3.71e-56: 190: 62.63		IF2B1_HUMAN (2-599): 2.29e-130: 395: 63.89
+	Hs
		1306035 ROAA_HUMAN (30-355): 3.41e-55: 185: 53.89		IF2B1_HUMAN (2-599): 2.29e-130: 395: 63.89
+	Hs
		128079 ROA3_HUMAN (64-265): 2.66e-50: 174: 37.02		IF2B3_HUMAN (2-599): 4.89e-134: 405: 62.36
+	Hs
		1048070 HNRPD_HUMAN (1-355): 9.1e-72: 229: 100.00		PCBP2_HUMAN (422-597): 7.25e-36: 140: 26.92
+	Hs
		1016054 Q12771_HUMAN (1-292): 6.63e-61: 198: 80.48		PCBP2_HUMAN (422-597): 7.25e-36: 140: 26.92
+	Hs
		1048181 HNRPD_HUMAN (1-355): 9.1e-72: 229: 100.00		FUBP3_HUMAN (196-414): 3.06e-18: 90.2: 15.51
+	Hs
		903934 HNRPD_HUMAN (1-355): 9.1e-72: 229: 100.00		HNRPK_HUMAN (386-596): 5.84e-18: 88.9: 17.09
+	Mm
		904259 HNRPD_MOUSE (1-355): 8.17e-72: 229: 95.49		HNRPK_MOUSE (386-596): 5.84e-18: 88.9: 17.09
+	Mm
		1112164 HNRPD_MOUSE (1-355): 8.17e-72: 229: 95.49		FUBP2_MOUSE (414-584): 5.84e-11: 67.4: 28.73
+	Hs
		1048165 HNRPD_HUMAN (1-355): 9.1e-72: 229: 100.00		FUBP2_HUMAN (414-584): 1.07e-10: 66.6: 28.73
+	Hs
		1048069 HNRPD_HUMAN (1-355): 9.1e-72: 229: 100.00		PCBP1_HUMAN (422-530): 8.21e-11: 65.8: 25.69
+	Hs
		162001 HNRDL_HUMAN (89-355): 3.71e-56: 190: 62.63		HNRPK_HUMAN (386-596): 5.84e-18: 88.9: 17.09
+	Mm
		904318 ROAA_MOUSE (29-305): 5.29e-52: 175: 50.71		HNRPK_MOUSE (386-596): 5.84e-18: 88.9: 17.09
+	Hs
		1016053 Q12771_HUMAN (1-292): 6.63e-61: 198: 80.48		PCBP1_HUMAN (422-530): 8.21e-11: 65.8: 25.69
+	Mm
		904286 ROA3_MOUSE (64-265): 2.72e-50: 174: 37.02		HNRPK_MOUSE (386-596): 5.84e-18: 88.9: 17.09
+	Hs
		852064 ROA3_HUMAN (64-265): 2.66e-50: 174: 37.02		PCBP1_HUMAN (422-530): 8.21e-11: 65.8: 25.69