HitPredict

Interactor 1: TOB2 (Q14106)
Protein Tob2 (Protein Tob4) (Transducer of erbB-2 2)
Gene: TOB2

Interactor 2: CNOT7 (Q9UIV1)
CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (BTG1-binding factor 1) (CCR4-associated factor 1) (CAF-1) (Caf1a)
Gene: CNOT7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	25416956, 32296183, 10602502, 26186194, 28514442, 33961781, unassigned1304
Identification Methods	two hybrid, pull down, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	BTG~CAF1
Common GO terms	GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 344 Hs			1 285
+	Hs
		1048316 TOB2_HUMAN (1-344): 1.73e-169: 477: 100.00		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Hs
		841404 TOB1_HUMAN (1-341): 4.33e-129: 374: 54.57		CNOT7_HUMAN (1-285): 0: 502: 100.00
+	Hs
		841403 TOB1_HUMAN (1-341): 4.33e-129: 374: 54.57		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Dm
		1155377 Q6NQY2_DROME (1-319): 2.42e-95: 294: 38.23		Q9VTS4_DROME (2-273): 2.28e-156: 439: 72.26
+	Mm
		251045 BTG4_MOUSE (1-258): 5.44e-74: 230: 21.13		CNOT7_MOUSE (1-285): 0: 501: 99.65
+	Hs
		1051207 BTG3_HUMAN (1-166): 6.66e-65: 207: 27.59		CNOT7_HUMAN (1-285): 0: 502: 100.00
+	Mm
		251046 BTG4_MOUSE (1-258): 5.44e-74: 230: 21.13		CNOT8_MOUSE (1-282): 1.11e-171: 477: 76.24
+	Dm
		60235 A4V4L0_DROME (1-319): 2.49e-92: 287: 37.40		X2JCC3_DROME (2-256): 5.58e-145: 412: 68.87
+	Hs
		1051204 BTG3_HUMAN (1-166): 6.66e-65: 207: 27.59		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Hs
		1152299 Q6IBC8_HUMAN (1-131): 8.94e-54: 176: 38.13		CNOT7_HUMAN (1-285): 0: 502: 100.00
+	Hs
		912794 BTG1_HUMAN (1-131): 8.94e-54: 176: 38.13		CNOT7_HUMAN (1-285): 0: 502: 100.00
+	Mm
		912801 BTG1_MOUSE (1-131): 8.94e-54: 176: 38.13		CNOT7_MOUSE (1-285): 0: 501: 99.65
+	Hs
		944599 BTG2_HUMAN (1-115): 3.44e-53: 174: 40.17		CNOT7_HUMAN (1-285): 0: 502: 100.00
+	Mm
		978994 BTG2_MOUSE (1-115): 1.01e-53: 175: 40.17		CNOT7_MOUSE (1-285): 0: 501: 99.65
+	Hs
		1152298 Q6IBC8_HUMAN (1-131): 8.94e-54: 176: 38.13		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Hs
		912793 BTG1_HUMAN (1-131): 8.94e-54: 176: 38.13		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Mm
		912802 BTG1_MOUSE (1-131): 8.94e-54: 176: 38.13		CNOT8_MOUSE (1-282): 1.11e-171: 477: 76.24
+	Hs
		944598 BTG2_HUMAN (1-115): 3.44e-53: 174: 40.17		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Mm
		978995 BTG2_MOUSE (1-115): 1.01e-53: 175: 40.17		CNOT8_MOUSE (1-282): 1.11e-171: 477: 76.24