HitPredict

Interactor 1: NID2 (Q14112)
Nidogen-2 (NID-2) (Osteonidogen)
Gene: NID2

Interactor 2: LAMA4 (Q16363)
Laminin subunit alpha-4 (Laminin-14 subunit alpha) (Laminin-8 subunit alpha) (Laminin-9 subunit alpha)
Gene: LAMA4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Laminin_EGF~Ldl_recept_b
Common GO terms	GO:0005201 - extracellular matrix structural constituent GO:0005576 - extracellular region GO:0005604 - basement membrane GO:0007155 - cell adhesion GO:0062023 - collagen-containing extracellular matrix and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1375 Hs			1 1823
+	Hs
		631066 NID2_HUMAN (1-1375): 0: 1047: 100.00		LAMA1_HUMAN (132-341): 2.44e-17: 91.2: 20.00
+	Hs
		502831 NID2_HUMAN (1-1375): 0: 1047: 100.00		LAMC1_HUMAN (13-132): 1.75e-13: 78.5: 20.93
+	Hs
		172664 NID2_HUMAN (1-1375): 0: 1047: 100.00		LAMA5_HUMAN (5-95): 2.97e-11: 71.1: 20.00
+	Hs
		877411 NID2_HUMAN (1-1375): 0: 1047: 100.00		LAMB2_HUMAN (26-118): 5.62e-11: 70.4: 22.00
+	Hs
		957540 NID2_HUMAN (1-1375): 0: 1047: 100.00		PGBM_HUMAN (87-168): 1.17e-10: 69.2: 17.65
+	Hs
		433149 NID2_HUMAN (1-1375): 0: 1047: 100.00		LAMB1_HUMAN (20-118): 1.77e-10: 68.5: 18.42
+	Hs
		129757 NID2_HUMAN (1-1375): 0: 1047: 100.00		AGRIN_HUMAN (123-200): 4.45e-10: 67.3: 17.65
+	Mm
		103556 NID2_MOUSE (27-1375): 0: 959: 79.25		G5E874_MOUSE (187-333): 4.04e-16: 86.9: 21.94
+	Mm
		358675 NID1_MOUSE (33-1373): 0: 595: 32.09		LAMC1_MOUSE (13-132): 5.81e-15: 83.5: 20.93
+	Mm
		489637 NID1_MOUSE (33-1373): 0: 595: 32.09		PGBM_MOUSE (77-168): 1.32e-11: 72.3: 21.74
+	Hs
		537530 NID1_HUMAN (28-1373): 0: 576: 32.19		LAMC3_HUMAN (13-133): 6.02e-16: 86.6: 23.85
+	Hs
		502808 NID1_HUMAN (28-1373): 0: 576: 32.19		LAMC1_HUMAN (13-132): 1.75e-13: 78.5: 20.93
+	Dm
		52252 A1Z7C4_DROME (447-779): 1.15e-10: 68.8: 9.37		LAMC1_DROME (154-334): 9.23e-27: 121: 26.98
+	Dm
		53032 NDG_DROME (292-804): 9.4e-20: 98.5: 9.98		LAMB1_DROME (187-319): 1.3e-13: 78.9: 19.57
+	Dm
		53035 NDG_DROME (292-804): 9.4e-20: 98.5: 9.98		LAMA_DROME (5-88): 8.92e-09: 63: 14.29
+	Dm
		52251 A1Z7C4_DROME (447-779): 1.15e-10: 68.8: 9.37		LAMB1_DROME (187-319): 1.3e-13: 78.9: 19.57
+	Dm
		52257 A1Z7C4_DROME (447-779): 1.15e-10: 68.8: 9.37		LAMA_DROME (5-88): 8.92e-09: 63: 14.29