HitPredict

Interactor 1: DPYS (Q14117)
Dihydropyrimidinase (DHP) (DHPase) (EC 3.5.2.2) (Dihydropyrimidine amidohydrolase) (Hydantoinase)
Gene: DPYS

Interactor 2: DPYL2 (Q16555)
Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2)
Gene: DPYSL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Amidohydro_1~Amidohydro_1
Common GO terms	GO:0004157 - dihydropyrimidinase activity GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 519 Hs			1 572
+	Hs
		1083101 DPYL2_HUMAN (3-519): 0: 659: 59.57		DPYL2_HUMAN (1-572): 0: 769: 100.00
+	Hs
		1048471 DPYS_HUMAN (1-519): 0: 683: 100.00		DPYL3_HUMAN (1-571): 0: 744: 76.71
+	Hs
		147330 DPYS_HUMAN (1-519): 0: 683: 100.00		DPYL4_HUMAN (1-571): 0: 740: 75.66
+	Hs
		1050867 DPYL2_HUMAN (3-519): 0: 659: 59.57		DPYL1_HUMAN (1-572): 0: 761: 76.22
+	Hs
		1050860 DPYL1_HUMAN (3-519): 0: 658: 58.41		DPYL1_HUMAN (1-572): 0: 761: 76.22
+	Hs
		1050861 DPYL3_HUMAN (3-519): 0: 658: 58.61		DPYL1_HUMAN (1-572): 0: 761: 76.22
+	Hs
		1050916 DPYL2_HUMAN (3-519): 0: 659: 59.57		DPYL3_HUMAN (1-571): 0: 744: 76.71
+	Hs
		1083118 DPYL2_HUMAN (3-519): 0: 659: 59.57		Q8IXW6_HUMAN (1-571): 0: 743: 76.53
+	Hs
		147335 DPYL2_HUMAN (3-519): 0: 659: 59.57		DPYL4_HUMAN (1-571): 0: 740: 75.66
+	Hs
		147331 DPYL1_HUMAN (3-519): 0: 658: 58.41		DPYL4_HUMAN (1-571): 0: 740: 75.66
+	Hs
		147332 DPYL3_HUMAN (3-519): 0: 658: 58.61		DPYL4_HUMAN (1-571): 0: 740: 75.66
+	Hs
		1083161 DPYL2_HUMAN (3-519): 0: 659: 59.57		X5DQV1_HUMAN (14-572): 0: 733: 76.03
+	Hs
		1048477 DPYS_HUMAN (1-519): 0: 683: 100.00		DPYL5_HUMAN (9-567): 0: 653: 51.34
+	Mm
		1322292 DPYS_MOUSE (1-518): 0: 681: 88.61		DPYL5_MOUSE (9-567): 0: 647: 50.62
+	Hs
		1083135 DPYL2_HUMAN (3-519): 0: 659: 59.57		DPYL5_HUMAN (9-567): 0: 653: 51.34
+	Hs
		1050937 DPYL3_HUMAN (3-519): 0: 658: 58.61		DPYL5_HUMAN (9-567): 0: 653: 51.34