HitPredict

Interactor 1: DSG2 (Q14126)
Desmoglein-2 (Cadherin family member 5) (HDGC)
Gene: DSG2

Interactor 2: STYK1 (Q6J9G0)
Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1)
Gene: STYK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	32707033, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1118 Hs			1 422
+	Hs
		507992 DSG2_HUMAN (1-1118): 0: 1174: 100.00		FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20
+	Hs
		601509 DSG2_HUMAN (1-1118): 0: 1174: 100.00		FGFR2_HUMAN (29-417): 7.84e-125: 382: 23.64
+	Hs
		665396 DSG2_HUMAN (1-1118): 0: 1174: 100.00		EPHA3_HUMAN (2-408): 7.62e-122: 378: 20.49
+	Hs
		872440 DSG2_HUMAN (1-1118): 0: 1174: 100.00		EPHA5_HUMAN (2-408): 4.94e-121: 377: 20.33
+	Hs
		1048589 DSG2_HUMAN (1-1118): 0: 1174: 100.00		EPHA7_HUMAN (36-414): 1.44e-120: 375: 19.37
+	Hs
		872645 DSG2_HUMAN (1-1118): 0: 1174: 100.00		EPHA4_HUMAN (42-417): 8.52e-119: 370: 18.73
+	Hs
		607964 DSG2_HUMAN (1-1118): 0: 1174: 100.00		FGFR4_HUMAN (80-392): 2.13e-119: 367: 28.79
+	Hs
		507929 CAD11_HUMAN (9-848): 0: 645: 22.22		FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20
+	Hs
		507817 CADH1_HUMAN (22-670): 0: 577: 31.67		FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20
+	Hs
		521744 CADH1_HUMAN (22-670): 0: 577: 31.67		EPHA2_HUMAN (46-411): 2.25e-121: 377: 21.95
+	Hs
		521694 CADH1_HUMAN (22-670): 0: 577: 31.67		SRC_HUMAN (90-390): 1.63e-110: 336: 28.95
+	Hs
		411968 CADH1_HUMAN (22-670): 0: 577: 31.67		FYN_HUMAN (92-390): 1.01e-109: 334: 28.33
+	Hs
		433230 CADH1_HUMAN (22-670): 0: 577: 31.67		YES_HUMAN (88-390): 1.93e-108: 331: 28.76
+	Mm
		544699 CADH2_MOUSE (17-839): 0: 675: 27.24		CSK_MOUSE (144-386): 3.9e-36: 139: 36.48
+	Hs
		508294 PCDB7_HUMAN (54-599): 4.83e-92: 314: 19.42		FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20
+	Xl
		292719 O93264_XENLA (1-493): 2.12e-78: 276: 18.63		FGFR1_XENLA (22-421): 1.1e-124: 381: 24.19
+	Hs
		433517 PCDB3_HUMAN (57-599): 1.32e-84: 293: 18.34		YES_HUMAN (88-390): 1.93e-108: 331: 28.76
+	Hs
		507842 CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52		FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20
+	Hs
		434134 CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52		RET_HUMAN (8-415): 2.01e-119: 375: 23.29
+	Hs
		580213 CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52		EPHA4_HUMAN (42-417): 8.52e-119: 370: 18.73