HitPredict

Interactor 1: TRI29 (Q14134)
Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein)
Gene: TRIM29

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	27695001, 20211142
Identification Methods	affinity chromatography technology, enzymatic study, two hybrid, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045087 - innate immune response
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 588 Hs			1 419
+	Mm
		291811 TRI29_MOUSE (1-588): 0: 586: 89.29		NEMO_MOUSE (1-419): 3e-53: 184: 86.64
+	Hs
		1318722 TRIM5_HUMAN (140-533): 1.09e-83: 271: 17.10		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		1223395 TRI22_HUMAN (147-519): 6.8e-79: 259: 16.75		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		585030 RO52_HUMAN (140-588): 2.7e-92: 293: 16.74		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		1078906 TRIM5_HUMAN (140-533): 1.09e-83: 271: 17.10		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Rn
		250674 TRIM3_RAT (136-566): 2.13e-76: 259: 15.96		MYO5B_RAT (61-394): 8.96e-25: 109: 17.85
+	Hs
		262202 TRIM3_HUMAN (136-566): 5.8e-77: 260: 15.75		MYO5A_HUMAN (38-342): 1.7e-24: 108: 14.65
+	Hs
		1078905 TRIM8_HUMAN (171-531): 3.4e-66: 227: 18.43		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Hs
		262200 TRIM3_HUMAN (136-566): 5.8e-77: 260: 15.75		MYO5B_HUMAN (64-394): 2.99e-18: 89.7: 16.95
+	Hs
		1261138 TRI41_HUMAN (182-393): 5.56e-42: 162: 22.07		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		311868 TRI16_HUMAN (104-419): 1.45e-55: 198: 24.47		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		1052815 TRI25_HUMAN (104-416): 2.68e-62: 218: 24.68		MYO5A_HUMAN (38-342): 1.7e-24: 108: 14.65
+	Hs
		522639 TRIM6_HUMAN (140-485): 2.68e-80: 262: 18.77		MYH7_HUMAN (26-376): 1.58e-09: 62.3: 13.24
+	Hs
		528393 TRIM6_HUMAN (140-485): 2.68e-80: 262: 18.77		MYH6_HUMAN (4-395): 1.4e-09: 62.3: 11.48
+	Hs
		1052799 TRI25_HUMAN (104-416): 2.68e-62: 218: 24.68		MYO5B_HUMAN (64-394): 2.99e-18: 89.7: 16.95
+	Hs
		1357714 TRI35_HUMAN (136-483): 1.7e-71: 239: 13.44		MRCKB_HUMAN (39-356): 2.85e-10: 64.7: 13.60