HitPredict

Interactor 1: GIT2 (Q14161)
ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)
Gene: GIT2

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 759 Hs			1 337
+	Hs
		1075477 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00
+	Hs
		153960 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		1049946 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		1050144 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Mm
		1143335 GIT1_MOUSE (1-758): 1.06e-139: 431: 63.43		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		1050094 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		1020239 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		PTN13_HUMAN (89-239): 2.59e-11: 66.9: 21.05
+	Hs
		1296967 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Mm
		100127 AGAP2_MOUSE (3-224): 1.24e-64: 236: 32.00		F6UDT8_MOUSE (4-328): 3.45e-48: 167: 18.92
+	Mm
		1112635 AGAP2_MOUSE (3-224): 1.24e-64: 236: 32.00		DLG2_MOUSE (79-232): 1.54e-14: 76.5: 18.63
+	Mm
		1112581 AGAP2_MOUSE (3-224): 1.24e-64: 236: 32.00		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Mm
		88312 AGAP2_MOUSE (3-224): 1.24e-64: 236: 32.00		D3YUZ8_MOUSE (129-232): 1.78e-14: 76.2: 25.23
+	Mm
		1112610 AGAP2_MOUSE (3-224): 1.24e-64: 236: 32.00		DLG1_MOUSE (87-235): 9.49e-14: 74.2: 17.31
+	Mm
		1143380 DAPK1_MOUSE (28-515): 5.41e-64: 234: 13.27		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		1020190 MIB1_HUMAN (54-671): 1.06e-66: 240: 11.62		PTN13_HUMAN (89-239): 2.59e-11: 66.9: 21.05
+	Hs
		1021587 ASAP1_HUMAN (3-656): 2.66e-63: 231: 15.57		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		1300695 AGAP1_HUMAN (3-224): 1.19e-59: 218: 33.33		MAGI1_HUMAN (2-204): 1.44e-16: 83.1: 21.95
+	Mm
		1112570 AGAP2_MOUSE (3-224): 1.24e-64: 236: 32.00		Q52KF7_MOUSE (89-220): 1.11e-09: 61.5: 17.99
+	Mm
		936177 AGAP2_MOUSE (3-224): 1.24e-64: 236: 32.00		DLG3_MOUSE (113-220): 5.5e-09: 59.6: 21.74
+	Hs
		1264864 ARAP2_HUMAN (7-186): 2.94e-51: 196: 32.24		LIN7C_HUMAN (9-87): 8.5e-09: 56.6: 40.74