HitPredict

Interactor 1: GIT2 (Q14161)
ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)
Gene: GIT2

Interactor 2: KCC4 (Q16566)
Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR)
Gene: CAMK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 759 Hs			1 473
+	Hs
		1083229 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		KCC4_HUMAN (1-473): 2.74e-164: 474: 100.00
+	Hs
		1357913 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		KCC2A_HUMAN (40-448): 1.11e-144: 424: 33.65
+	Rn
		506783 GIT1_RAT (1-758): 5.37e-138: 427: 63.43		KCC2A_RAT (40-448): 1.05e-144: 424: 33.65
+	Mm
		1112593 AGAP2_MOUSE (3-224): 1.24e-64: 236: 32.00		KCC2D_MOUSE (40-448): 2.01e-144: 424: 35.10
+	Mm
		515228 AGAP2_MOUSE (3-224): 1.24e-64: 236: 32.00		KCC2A_MOUSE (40-448): 1.05e-144: 424: 33.65
+	Mm
		1112637 AGAP2_MOUSE (3-224): 1.24e-64: 236: 32.00		KCC2G_MOUSE (40-448): 6.95e-144: 423: 34.42
+	Rn
		506765 AGAP2_RAT (3-224): 3.29e-64: 234: 32.00		KCC2A_RAT (40-448): 1.05e-144: 424: 33.65
+	Mm
		659450 AGAP2_MOUSE (3-224): 1.24e-64: 236: 32.00		KCC2B_MOUSE (40-448): 3.08e-143: 422: 31.60
+	Hs
		166938 ANR28_HUMAN (204-531): 7.26e-32: 135: 9.09		KCC4_HUMAN (1-473): 2.74e-164: 474: 100.00
+	Hs
		166632 AGAP1_HUMAN (3-224): 1.19e-59: 218: 33.33		DCLK1_HUMAN (10-368): 5.47e-69: 235: 37.27
+	Hs
		166610 FEM1A_HUMAN (161-274): 5.1e-13: 74.8: 16.91		DCLK1_HUMAN (10-368): 5.47e-69: 235: 37.27