HitPredict

Interactor 1: GIT2 (Q14161)
ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)
Gene: GIT2

Interactor 2: RHOV (Q96L33)
Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2)
Gene: RHOV

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Ras
Common GO terms	GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 759 Hs			1 236
+	Hs
		1050126 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48
+	Hs
		950990 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		RHOG_HUMAN (31-210): 1.12e-78: 236: 49.44
+	Hs
		925274 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Hs
		892368 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		RAC3_HUMAN (32-206): 6.17e-74: 224: 56.00
+	Hs
		564527 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		RHOQ_HUMAN (23-236): 1.99e-73: 223: 50.00
+	Hs
		545371 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		RAC2_HUMAN (32-216): 6.11e-73: 222: 52.43
+	Hs
		894000 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39
+	Hs
		1050152 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		RHOJ_HUMAN (32-214): 8.3e-59: 186: 50.27
+	Hs
		1183621 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48
+	Hs
		951478 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		RHOG_HUMAN (31-210): 1.12e-78: 236: 49.44
+	Hs
		1296770 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		RHOV_HUMAN (1-236): 3.37e-76: 231: 100.00
+	Hs
		925751 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Gg
		1154344 Q9DG15_CHICK (1-758): 1.05e-140: 433: 64.96		Q6LC82_CHICK (32-217): 3.34e-76: 230: 53.23
+	Hs
		892692 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		RAC3_HUMAN (32-206): 6.17e-74: 224: 56.00
+	Hs
		564752 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		RHOQ_HUMAN (23-236): 1.99e-73: 223: 50.00
+	Hs
		545710 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		RAC2_HUMAN (32-216): 6.11e-73: 222: 52.43
+	Hs
		894610 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39
+	Hs
		1331002 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		RHOJ_HUMAN (32-214): 8.3e-59: 186: 50.27
+	Dm
		185486 GIT_DROME (9-613): 6.41e-76: 261: 35.36		O18332_DROME (21-234): 4.65e-75: 227: 21.01
+	Mm
		892722 AGAP2_MOUSE (3-224): 1.24e-64: 236: 32.00		CDC42_MOUSE (32-207): 2.12e-66: 205: 57.39