HitPredict

Interactor 1: GIT2 (Q14161)
ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)
Gene: GIT2

Interactor 2: GIT1 (Q9Y2X7)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)
Gene: GIT1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.907

The method score is based on:

Property Details
Experiments 12473661, 28514442, 33961781, 16628223
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ank_2~Ank_2, Ank_2~ArfGap, Ank_2~GIT_SHD, ArfGap~ArfGap, ArfGap~GIT_SHD, GIT1_C~GIT1_C, GIT_CC~GIT_CC, GIT_SHD~GIT_SHD
Common GO terms GO:0005096 - GTPase activator activity
GO:0005925 - focal adhesion
GO:0007420 - brain development
GO:0008277 - regulation of G protein-coupled receptor signaling pathway
GO:0031267 - small GTPase binding
and 4 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 759
Hs

1 761
+ Gg
+ Hs
+ Hs
+ Rn
+ Mm
+ Mm
+ Mm
+ Mm
+ Hs
+ Hs
+ At
+ Hs
+ Hs
+ Mm

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Last updated: 15 Jul 2024