Interactor 1: IKKE (Q14164)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: IKBKE

Interactor 2: STING (Q86WV6)
Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173)
Gene: STING1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 0.60 0.702

The method score is based on:

Property Details
Experiments 22312431, 37130168, 28346439, 19433799, 18818105
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0031625 - ubiquitin protein ligase binding
GO:0032481 - positive regulation of type I interferon production
GO:0051091 - positive regulation of DNA-binding transcription factor activity
and 3 others

more...

Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 716
Hs

1 379
+ Mm
+ Hs
+ Mm
+ Mm
+ Hs
+ Mm

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Last updated: 15 Jul 2024