HitPredict

Interactor 1: IKKE (Q14164)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: IKBKE

Interactor 2: CYLD (Q9NQC7)
Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)
Gene: CYLD

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.689

Property	Details
Experiments	29755980, 18636086, 23453969, 19481526
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation, in-gel kinase assay
Interaction Type	direct interaction, physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 716 Hs			1 956
+	Hs
		1343361 TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		254517 ROCK2_HUMAN (7-705): 1.81e-120: 393: 16.15		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		262321 ULK1_HUMAN (2-221): 1.05e-23: 109: 31.72		CYLD_HUMAN (1-956): 0: 1872: 100.00