HitPredict

Interactor 1: IKKE (Q14164)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: IKBKE

Interactor 2: Q9UQC1 (Q9UQC1)
Heat shock protein 72
Gene: HSP70-1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 716 Hs			1 151
+	Hs
		1050214 IKKE_HUMAN (1-716): 1.32e-170: 508: 100.00		Q53FC7_HUMAN (1-150): 1.89e-77: 243: 84.67
+	Hs
		504064 IKKE_HUMAN (1-716): 1.32e-170: 508: 100.00		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		1355361 TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13		Q9UQC1_HUMAN (1-151): 8.55e-83: 241: 100.00
+	Hs
		504911 TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		158571 IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97		Q9UQC1_HUMAN (1-151): 8.55e-83: 241: 100.00
+	Hs
		158411 IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97		HS71L_HUMAN (1-150): 2.61e-76: 240: 91.33
+	Hs
		158382 IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		254440 ROCK2_HUMAN (7-705): 1.81e-120: 393: 16.15		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		167636 IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31		Q9UQC1_HUMAN (1-151): 8.55e-83: 241: 100.00
+	Sc
		419765 SNF1_YEAST (9-487): 5.7e-101: 325: 17.23		HSP73_YEAST (2-150): 8.28e-77: 241: 80.54
+	Sc
		419774 SNF1_YEAST (9-487): 5.7e-101: 325: 17.23		HSP71_YEAST (1-150): 2.5e-75: 237: 78.67
+	Hs
		564041 KS6A3_HUMAN (6-294): 2.42e-88: 294: 22.34		HSP76_HUMAN (1-150): 3.19e-78: 245: 85.33
+	Hs
		564080 KS6A1_HUMAN (4-348): 2.36e-88: 294: 20.17		HSP76_HUMAN (1-150): 3.19e-78: 245: 85.33
+	Hs
		503719 KS6A3_HUMAN (6-294): 2.42e-88: 294: 22.34		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		504119 KS6A1_HUMAN (4-348): 2.36e-88: 294: 20.17		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Dm
		505090 IKKB_DROME (1-317): 5.09e-29: 125: 31.77		HSP7D_DROME (1-150): 2.33e-78: 245: 84.67
+	Dm
		669799 IKKB_DROME (1-317): 5.09e-29: 125: 31.77		HSP7A_DROME (1-150): 5.24e-77: 242: 82.67
+	Dm
		1213523 IKKB_DROME (1-317): 5.09e-29: 125: 31.77		HSP72_DROME (1-150): 1.49e-76: 240: 83.44
+	Dm
		365410 IKKB_DROME (1-317): 5.09e-29: 125: 31.77		HSP71_DROME (1-150): 1.8e-76: 240: 83.44
+	Dm
		332639 IKKB_DROME (1-317): 5.09e-29: 125: 31.77		HSP68_DROME (1-150): 1.65e-75: 238: 81.46