HitPredict

Interactor 1: DOCK1 (Q14185)
Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
Gene: DOCK1

Interactor 2: ELMO2 (Q96JJ3)
Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A)
Gene: ELMO2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	32203420
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DOCK_N~PH_12
Common GO terms	GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1865 Hs			1 720
+	Mm
		1206593 DOCK1_MOUSE (1-1865): 0: 2189: 96.46		ELMO2_MOUSE (1-720): 0: 1042: 97.13
+	Mm
		1207128 DOCK1_MOUSE (1-1865): 0: 2189: 96.46		ELMO1_MOUSE (1-718): 0: 1010: 75.34
+	Hs
		1050484 DOCK1_HUMAN (1-1865): 0: 2184: 100.00		ELMO1_HUMAN (1-718): 0: 1012: 75.48
+	Mm
		1207312 DOCK1_MOUSE (1-1865): 0: 2189: 96.46		ELMO3_MOUSE (1-719): 0: 944: 51.11
+	Hs
		1050487 DOCK1_HUMAN (1-1865): 0: 2184: 100.00		ELMO3_HUMAN (1-718): 0: 944: 50.49
+	Hs
		1267934 DOCK2_HUMAN (1-1805): 0: 1960: 59.80		ELMO2_HUMAN (1-720): 0: 1053: 100.00
+	Hs
		1295265 DOCK5_HUMAN (1-1844): 0: 1934: 62.63		ELMO2_HUMAN (1-720): 0: 1053: 100.00
+	Hs
		1267020 DOCK2_HUMAN (1-1805): 0: 1960: 59.80		ELMO1_HUMAN (1-718): 0: 1012: 75.48
+	Hs
		1267024 DOCK5_HUMAN (1-1844): 0: 1934: 62.63		ELMO1_HUMAN (1-718): 0: 1012: 75.48
+	Mm
		1207130 DOCK2_MOUSE (1-1782): 0: 1919: 60.11		ELMO1_MOUSE (1-718): 0: 1010: 75.34
+	Hs
		1285559 DOCK5_HUMAN (1-1844): 0: 1934: 62.63		ELMO3_HUMAN (1-718): 0: 944: 50.49
+	Hs
		1224227 DOCK3_HUMAN (4-1851): 0: 1771: 36.75		ELMO2_HUMAN (1-720): 0: 1053: 100.00
+	Hs
		1230992 DOCK4_HUMAN (4-1855): 0: 1748: 36.35		ELMO2_HUMAN (1-720): 0: 1053: 100.00
+	Hs
		1224220 DOCK3_HUMAN (4-1851): 0: 1771: 36.75		ELMO1_HUMAN (1-718): 0: 1012: 75.48
+	Hs
		1061751 Q149N5_HUMAN (4-1855): 0: 1718: 35.37		ELMO2_HUMAN (1-720): 0: 1053: 100.00
+	Hs
		1230987 DOCK4_HUMAN (4-1855): 0: 1748: 36.35		ELMO1_HUMAN (1-718): 0: 1012: 75.48
+	Hs
		1224225 DOCK3_HUMAN (4-1851): 0: 1771: 36.75		ELMO3_HUMAN (1-718): 0: 944: 50.49
+	Hs
		1230990 DOCK4_HUMAN (4-1855): 0: 1748: 36.35		ELMO3_HUMAN (1-718): 0: 944: 50.49
+	Dm
		1362934 Q9VCH4_DROME (1-1822): 0: 1783: 38.87		Q9VKB2_DROME (5-718): 0: 839: 44.60
+	Dm
		81396 B7Z0R2_DROME (4-1748): 0: 1647: 36.31		Q9VKB2_DROME (5-718): 0: 839: 44.60