HitPredict

Interactor 1: TFDP2 (Q14188)
Transcription factor Dp-2 (E2F dimerization partner 2)
Gene: TFDP2

Interactor 2: E2F5 (Q15329)
Transcription factor E2F5 (E2F-5)
Gene: E2F5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DP~E2F_CC-MB, E2F_TDP~E2F_TDP
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0090575 - RNA polymerase II transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 446 Hs			1 346
+	Mm
		1142630 TFDP2_MOUSE (1-432): 0: 654: 91.67		E2F5_MOUSE (1-346): 4.15e-133: 384: 87.57
+	Hs
		1050505 TFDP1_HUMAN (3-430): 0: 624: 60.47		E2F5_HUMAN (1-346): 6.29e-137: 394: 100.00
+	Hs
		1050552 TFDP2_HUMAN (1-446): 0: 700: 100.00		E2F2_HUMAN (10-340): 1.51e-101: 307: 35.00
+	Hs
		135248 TFDP2_HUMAN (1-446): 0: 700: 100.00		E2F3_HUMAN (8-340): 3.77e-100: 305: 32.64
+	Hs
		963616 TFDP2_HUMAN (1-446): 0: 700: 100.00		E2F1_HUMAN (10-340): 1.7e-95: 292: 29.54
+	Mm
		405 A0A087WPU8_MOUSE (1-431): 0: 696: 95.36		E2F2_MOUSE (10-340): 2.42e-96: 294: 33.79
+	Mm
		406 A0A087WPU8_MOUSE (1-431): 0: 696: 95.36		E2F1_MOUSE (32-340): 1.02e-93: 287: 34.25
+	Hs
		1050501 TFDP1_HUMAN (3-430): 0: 624: 60.47		E2F2_HUMAN (10-340): 1.51e-101: 307: 35.00
+	Hs
		135247 TFDP1_HUMAN (3-430): 0: 624: 60.47		E2F3_HUMAN (8-340): 3.77e-100: 305: 32.64
+	Hs
		265646 TFDP2_HUMAN (1-446): 0: 700: 100.00		E2F6_HUMAN (50-258): 9.84e-70: 220: 36.02
+	Hs
		963615 TFDP1_HUMAN (3-430): 0: 624: 60.47		E2F1_HUMAN (10-340): 1.7e-95: 292: 29.54
+	Mm
		996142 TFDP1_MOUSE (3-430): 0: 607: 59.82		E2F1_MOUSE (32-340): 1.02e-93: 287: 34.25
+	Mm
		99867 F6QG91_MOUSE (62-431): 0: 594: 95.42		E2F2_MOUSE (10-340): 2.42e-96: 294: 33.79
+	Mm
		99869 F6QG91_MOUSE (62-431): 0: 594: 95.42		E2F1_MOUSE (32-340): 1.02e-93: 287: 34.25
+	Hs
		265645 TFDP1_HUMAN (3-430): 0: 624: 60.47		E2F6_HUMAN (50-258): 9.84e-70: 220: 36.02
+	Hs
		135260 TFDP3_HUMAN (3-435): 2.07e-178: 506: 47.15		E2F3_HUMAN (8-340): 3.77e-100: 305: 32.64
+	Hs
		1050555 TFDP2_HUMAN (1-446): 0: 700: 100.00		E2F4_HUMAN (268-345): 2.71e-13: 72.2: 43.37
+	Mm
		1145033 TFDP2_MOUSE (1-432): 0: 654: 91.67		E2F4_MOUSE (268-344): 1.61e-12: 69.9: 42.68
+	Hs
		1050507 TFDP1_HUMAN (3-430): 0: 624: 60.47		E2F4_HUMAN (268-345): 2.71e-13: 72.2: 43.37
+	Mm
		996145 TFDP1_MOUSE (3-430): 0: 607: 59.82		E2F4_MOUSE (268-344): 1.61e-12: 69.9: 42.68