HitPredict

Interactor 1: DPYL3 (Q14195)
Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1)
Gene: DPYSL3

Interactor 2: DPYL5 (Q9BPU6)
Dihydropyrimidinase-related protein 5 (DRP-5) (CRMP3-associated molecule) (CRAM) (Collapsin response mediator protein 5) (CRMP-5) (UNC33-like phosphoprotein 6) (ULIP-6)
Gene: DPYSL5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	32296183, 28514442, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Amidohydro_1~Amidohydro_1
Common GO terms	GO:0005829 - cytosol GO:0016812 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 570 Hs			1 564
+	Hs
		1050861 DPYL3_HUMAN (1-570): 0: 765: 100.00		DPYL1_HUMAN (6-561): 0: 729: 50.81
+	Hs
		1050916 DPYL3_HUMAN (1-570): 0: 765: 100.00		DPYL2_HUMAN (6-561): 0: 726: 51.71
+	Hs
		1083118 Q8IXW6_HUMAN (1-570): 0: 765: 99.83		DPYL2_HUMAN (6-561): 0: 726: 51.71
+	Mm
		1143651 DPYL3_MOUSE (1-570): 0: 764: 98.42		DPYL5_MOUSE (1-564): 0: 723: 97.87
+	Mm
		956446 DPYL3_MOUSE (1-570): 0: 764: 98.42		DPYL1_MOUSE (6-561): 0: 723: 50.27
+	Hs
		147332 DPYL3_HUMAN (1-570): 0: 765: 100.00		DPYL4_HUMAN (6-561): 0: 715: 49.46
+	Hs
		1050860 DPYL1_HUMAN (1-569): 0: 748: 74.43		DPYL1_HUMAN (6-561): 0: 729: 50.81
+	Hs
		1050867 DPYL1_HUMAN (1-569): 0: 748: 74.43		DPYL2_HUMAN (6-561): 0: 726: 51.71
+	Hs
		1083135 DPYL2_HUMAN (1-569): 0: 742: 76.71		DPYL5_HUMAN (1-564): 0: 727: 100.00
+	Hs
		1083101 DPYL2_HUMAN (1-569): 0: 742: 76.71		DPYL2_HUMAN (6-561): 0: 726: 51.71
+	Hs
		1083161 DPYL2_HUMAN (1-569): 0: 742: 76.71		X5DQV1_HUMAN (4-561): 0: 725: 50.81
+	Rn
		815101 DPYL2_RAT (1-569): 0: 740: 77.41		DPYL2_RAT (6-561): 0: 725: 52.24
+	Hs
		147331 DPYL1_HUMAN (1-569): 0: 748: 74.43		DPYL4_HUMAN (6-561): 0: 715: 49.46
+	Hs
		147335 DPYL2_HUMAN (1-569): 0: 742: 76.71		DPYL4_HUMAN (6-561): 0: 715: 49.46
+	Hs
		1048471 DPYL3_HUMAN (1-570): 0: 765: 100.00		DPYS_HUMAN (5-518): 0: 665: 57.53
+	Hs
		1048473 DPYL2_HUMAN (1-569): 0: 742: 76.71		DPYS_HUMAN (5-518): 0: 665: 57.53