HitPredict

Interactor 1: DCTN1 (Q14203)
Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued)
Gene: DCTN1

Interactor 2: MACF1 (Q9UPN3)
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)
Gene: MACF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005874 - microtubule GO:0016020 - membrane GO:0031122 - cytoplasmic microtubule organization
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1278 Hs			1 7388
+	Hs
		725073 MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54		MACF1_HUMAN (1-7388): 0: 2387: 100.00
+	Hs
		110636 MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54		H3BPE1_HUMAN (66-7004): 0: 1955: 82.41
+	Hs
		974072 DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		963324 DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		885258 MRCKA_HUMAN (154-593): 9.15e-20: 98.4: 15.64		EPIPL_HUMAN (1538-2789): 1.49e-35: 154: 13.15
+	Mm
		93578 DESP_MOUSE (177-1018): 4.44e-14: 80: 13.33		PLEC_MOUSE (5698-7245): 3.41e-29: 132: 9.08
+	Mm
		93570 MYH9_MOUSE (826-1275): 8.37e-15: 82.2: 10.13		DESP_MOUSE (2737-3805): 1.11e-27: 127: 8.89
+	Hs
		724839 MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		551596 DESP_HUMAN (227-1049): 1.36e-14: 81.5: 14.64		DESP_HUMAN (2737-3775): 9.21e-27: 124: 8.65
+	Hs
		974110 CLIP4_HUMAN (6-95): 3.79e-26: 118: 42.22		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		522612 MYH7_HUMAN (64-763): 2.65e-27: 122: 9.80		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		724786 MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		164575 MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54		SPTN2_HUMAN (3436-4815): 1.06e-11: 74.8: 9.59
+	Hs
		724781 MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		521484 MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07
+	Hs
		724817 MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39