HitPredict

Interactor 1: IF4A2 (Q14240)
Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)
Gene: EIF4A2

Interactor 2: PDCD4 (Q53EL6)
Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a)
Gene: PDCD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.930

Property	Details
Experiments	32296183, 25416956, 17353931, 29395067, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, proximity labelling technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DEAD~MA3, Helicase_C~MA3
Common GO terms	GO:0003723 - RNA binding GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 407 Hs			1 469
+	Mm
		892950 IF4A1_MOUSE (3-407): 2.35e-159: 456: 89.88		PDCD4_MOUSE (1-469): 0: 572: 96.80
+	Hs
		892823 IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88		PDCD4_HUMAN (1-469): 0: 570: 100.00
+	Hs
		757641 IF4A3_HUMAN (3-407): 2.28e-130: 382: 67.65		PDCD4_HUMAN (1-469): 0: 570: 100.00
+	Dm
		972167 IF4A_DROME (14-407): 0: 510: 73.86		Q9VY91_DROME (49-469): 2.08e-134: 399: 36.77
+	Hs
		203355 IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88		IF4G3_HUMAN (276-440): 3.2e-43: 165: 20.00
+	Hs
		892779 IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88		IF4G1_HUMAN (319-439): 2.34e-36: 145: 24.79
+	At
		1275773 IF4A3_ARATH (8-407): 3.62e-158: 453: 69.25		IF4G1_ARATH (304-447): 4.92e-37: 146: 23.61
+	Mm
		892952 IF4A1_MOUSE (3-407): 2.35e-159: 456: 89.88		IF4G1_MOUSE (319-439): 1.35e-35: 143: 23.14
+	Hs
		892776 IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88		IF4G2_HUMAN (319-434): 1.33e-25: 112: 26.05
+	Hs
		203371 IF4A2_HUMAN (1-407): 2.49e-129: 380: 100.00		IF4G3_HUMAN (276-440): 3.2e-43: 165: 20.00
+	Hs
		133990 DDX3X_HUMAN (2-406): 3.77e-128: 385: 29.51		IF4G1_HUMAN (319-439): 2.34e-36: 145: 24.79
+	Hs
		757578 IF4A3_HUMAN (3-407): 2.28e-130: 382: 67.65		IF4G1_HUMAN (319-439): 2.34e-36: 145: 24.79
+	Hs
		979902 IF4A2_HUMAN (1-407): 2.49e-129: 380: 100.00		IF4G1_HUMAN (319-439): 2.34e-36: 145: 24.79
+	Hs
		133973 DDX3X_HUMAN (2-406): 3.77e-128: 385: 29.51		IF4G2_HUMAN (319-434): 1.33e-25: 112: 26.05
+	Hs
		941985 IF4A2_HUMAN (1-407): 2.49e-129: 380: 100.00		IF4G2_HUMAN (319-434): 1.33e-25: 112: 26.05