HitPredict

Interactor 1: TRI25 (Q14258)
E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)
Gene: TRIM25

Interactor 2: UBP10 (Q14694)
Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)
Gene: USP10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34416231, 29395067
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 630 Hs			1 798
+	Hs
		1058230 TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73		UBP10_HUMAN (1-798): 0: 720: 100.00
+	Mm
		854516 TRI29_MOUSE (96-454): 7.75e-60: 212: 22.28		UBP10_MOUSE (1-798): 0: 690: 83.23
+	Hs
		1058275 TRI11_HUMAN (6-288): 2.34e-31: 129: 19.08		UBP10_HUMAN (1-798): 0: 720: 100.00
+	Hs
		271214 TRIM1_HUMAN (3-629): 8.74e-115: 361: 20.58		UBP2_HUMAN (161-793): 7.79e-111: 352: 16.82
+	Hs
		271188 TRIM9_HUMAN (4-591): 2.11e-79: 267: 14.85		UBP2_HUMAN (161-793): 7.79e-111: 352: 16.82
+	Hs
		777049 TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73		UBP8_HUMAN (61-793): 7.74e-115: 376: 18.02
+	Hs
		271187 TRIM8_HUMAN (7-358): 1.75e-77: 258: 25.21		UBP2_HUMAN (161-793): 7.79e-111: 352: 16.82
+	Hs
		271128 TRI46_HUMAN (4-622): 3.72e-69: 241: 15.24		UBP2_HUMAN (161-793): 7.79e-111: 352: 16.82
+	Hs
		1318685 TRIM9_HUMAN (4-591): 2.11e-79: 267: 14.85		UBP21_HUMAN (200-793): 7.22e-100: 322: 16.69
+	Hs
		1318357 TRIM8_HUMAN (7-358): 1.75e-77: 258: 25.21		UBP21_HUMAN (200-793): 7.22e-100: 322: 16.69
+	Hs
		1172289 TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73		UBP22_HUMAN (374-795): 4.81e-87: 287: 19.17
+	Hs
		271189 TRIM5_HUMAN (2-281): 6.42e-32: 131: 15.19		UBP2_HUMAN (161-793): 7.79e-111: 352: 16.82
+	Hs
		271027 TRI27_HUMAN (2-358): 2.11e-31: 130: 14.40		UBP2_HUMAN (161-793): 7.79e-111: 352: 16.82
+	Hs
		271195 TRI39_HUMAN (4-351): 6.55e-31: 128: 17.40		UBP2_HUMAN (161-793): 7.79e-111: 352: 16.82
+	Hs
		1318717 TRIM5_HUMAN (2-281): 6.42e-32: 131: 15.19		UBP21_HUMAN (200-793): 7.22e-100: 322: 16.69
+	Hs
		271032 RO52_HUMAN (72-325): 5.42e-14: 76.6: 13.36		UBP2_HUMAN (161-793): 7.79e-111: 352: 16.82
+	Hs
		271221 TRI35_HUMAN (9-80): 1.95e-10: 65.5: 45.21		UBP2_HUMAN (161-793): 7.79e-111: 352: 16.82
+	Hs
		1173835 TRI35_HUMAN (9-80): 1.95e-10: 65.5: 45.21		UBP49_HUMAN (362-797): 1.38e-81: 277: 15.45