HitPredict

Interactor 1: TRI25 (Q14258)
E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)
Gene: TRIM25

Interactor 2: TAB2 (Q9NYJ8)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)
Gene: TAB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32024699
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 630 Hs			1 693
+	Hs
		1048809 TRI29_HUMAN (84-348): 1.63e-61: 216: 28.67		TAB2_HUMAN (1-693): 1.25e-111: 354: 100.00
+	Mm
		1246829 TRI29_MOUSE (96-454): 7.75e-60: 212: 22.28		TAB2_MOUSE (1-693): 7.87e-108: 344: 94.66
+	Hs
		1318714 TRIM5_HUMAN (2-281): 6.42e-32: 131: 15.19		TAB2_HUMAN (1-693): 1.25e-111: 354: 100.00
+	Hs
		537101 TRI27_HUMAN (2-358): 2.11e-31: 130: 14.40		TAB2_HUMAN (1-693): 1.25e-111: 354: 100.00
+	Hs
		1223392 TRI22_HUMAN (6-291): 7.57e-31: 128: 16.50		TAB2_HUMAN (1-693): 1.25e-111: 354: 100.00
+	Hs
		1170634 TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73		PHLB1_HUMAN (44-596): 6.26e-34: 141: 14.08
+	Hs
		1234340 TRIM5_HUMAN (2-281): 6.42e-32: 131: 15.19		TAB3_HUMAN (1-692): 2.31e-70: 245: 29.77
+	Hs
		536926 TRI27_HUMAN (2-358): 2.11e-31: 130: 14.40		TAB3_HUMAN (1-692): 2.31e-70: 245: 29.77
+	Hs
		1170566 TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73		MICA3_HUMAN (139-605): 2.54e-25: 114: 11.18
+	Hs
		554346 BT2A2_HUMAN (448-628): 3.81e-79: 261: 28.73		MUC1_HUMAN (23-434): 8.02e-18: 90.2: 8.89
+	Hs
		979898 TRI14_HUMAN (155-624): 1.74e-75: 249: 18.45		IF4G1_HUMAN (71-521): 3.73e-21: 101: 8.28
+	Hs
		979931 TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73		IF4G1_HUMAN (71-521): 3.73e-21: 101: 8.28
+	Hs
		257667 TRI41_HUMAN (197-628): 1.4e-79: 266: 16.70		ANR17_HUMAN (117-519): 7.6e-10: 64.7: 11.54
+	Hs
		135034 TRI38_HUMAN (97-469): 9.69e-11: 66.2: 12.62		TAB3_HUMAN (1-692): 2.31e-70: 245: 29.77
+	Hs
		846806 TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73		SMCA2_HUMAN (127-396): 1.06e-10: 67.5: 10.22
+	Hs
		257636 TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73		ANR17_HUMAN (117-519): 7.6e-10: 64.7: 11.54
+	Hs
		1170060 TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73		SRCAP_HUMAN (28-590): 2.21e-09: 63.2: 8.69
+	Hs
		203236 TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73		SYNJ1_HUMAN (303-658): 3.22e-09: 62.5: 9.55
+	Hs
		847001 TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73		SMCA4_HUMAN (111-415): 6.46e-09: 61.7: 8.81
+	Hs
		537122 TRI27_HUMAN (2-358): 2.11e-31: 130: 14.40		MAGL2_HUMAN (37-544): 1.37e-09: 63.6: 8.02