HitPredict

Interactor 1: FLNC (Q14315)
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
Gene: FLNC

Interactor 2: ANS1B (Q7Z6G8)
Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1)
Gene: ANKS1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 2725 Hs			1 1248
+	Hs
		1021400 FLNC_HUMAN (1-2725): 0: 2507: 100.00		ANK3_HUMAN (1-322): 2.7e-68: 256: 25.75
+	Rn
		88611 FLNC_RAT (1-2725): 0: 2498: 98.24		ANK3_RAT (1-322): 7.47e-71: 264: 25.75
+	Hs
		1052945 FLNC_HUMAN (1-2725): 0: 2507: 100.00		TANC2_HUMAN (104-807): 1.54e-29: 130: 11.73
+	Hs
		598330 FLNA_HUMAN (167-2725): 0: 1226: 35.27		TANC2_HUMAN (104-807): 1.54e-29: 130: 11.73
+	Hs
		261332 FLNB_HUMAN (146-2725): 0: 1198: 35.18		TANC2_HUMAN (104-807): 1.54e-29: 130: 11.73
+	Hs
		963306 SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12		ANK3_HUMAN (1-322): 2.7e-68: 256: 25.75
+	Hs
		556695 SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12		ANK1_HUMAN (118-1056): 8.3e-52: 202: 10.29
+	Dr
		1186355 Q7SYE2_DANRE (2-387): 1.64e-124: 419: 27.25		MIB1_DANRE (2-184): 8.19e-32: 137: 23.27
+	Dr
		1103596 Q2YDR5_DANRE (1-387): 8.74e-123: 414: 26.73		MIB1_DANRE (2-184): 8.19e-32: 137: 23.27
+	Dr
		1186354 Q7SYD3_DANRE (12-388): 8.49e-123: 414: 26.85		MIB1_DANRE (2-184): 8.19e-32: 137: 23.27
+	Mm
		103603 SPTB2_MOUSE (26-266): 1.26e-100: 365: 38.12		ANK3_MOUSE (159-1174): 7.86e-30: 131: 11.86
+	Hs
		521508 ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30		DAPK1_HUMAN (49-213): 9.81e-12: 72: 32.12
+	Hs
		211541 ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68		DAPK1_HUMAN (49-213): 9.81e-12: 72: 32.12
+	Hs
		862027 SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12		DAPK1_HUMAN (49-213): 9.81e-12: 72: 32.12
+	Hs
		963292 SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12		ANK2_HUMAN (66-258): 2.91e-10: 67.4: 30.05
+	Hs
		506803 SPTB1_HUMAN (37-257): 1.25e-35: 152: 38.33		ANK1_HUMAN (118-1056): 8.3e-52: 202: 10.29
+	Hs
		556716 TITIN_HUMAN (1554-2636): 3.13e-09: 65.5: 10.78		ANK1_HUMAN (118-1056): 8.3e-52: 202: 10.29
+	Hs
		166985 TITIN_HUMAN (1554-2636): 3.13e-09: 65.5: 10.78		ANR28_HUMAN (151-506): 3.18e-28: 125: 14.25