HitPredict

Interactor 1: FLNC (Q14315)
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
Gene: FLNC

Interactor 2: IGSF8 (Q969P0)
Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes-associated transmembrane protein 4) (KCT-4) (LIR-D1) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316)
Gene: IGSF8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23463506
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2725 Hs			1 613
+	Hs
		255772 FLNC_HUMAN (1-2725): 0: 2507: 100.00		OBSL1_HUMAN (92-559): 2.57e-11: 69.3: 15.13
+	Hs
		598261 FLNA_HUMAN (167-2725): 0: 1226: 35.27		IGSF8_HUMAN (1-613): 5.61e-173: 507: 100.00
+	Hs
		598253 FLNA_HUMAN (167-2725): 0: 1226: 35.27		TITIN_HUMAN (169-612): 1.96e-12: 72.9: 9.60
+	Hs
		255501 FLNA_HUMAN (167-2725): 0: 1226: 35.27		OBSL1_HUMAN (92-559): 2.57e-11: 69.3: 15.13
+	Hs
		255374 FLNB_HUMAN (146-2725): 0: 1198: 35.18		OBSL1_HUMAN (92-559): 2.57e-11: 69.3: 15.13
+	Mm
		1161055 FLNB_MOUSE (146-2725): 0: 1194: 34.74		MYLK_MOUSE (55-280): 1.7e-10: 66.4: 10.82
+	Dm
		1337379 FLNA_DROME (758-2724): 0: 1012: 33.19		TITIN_DROME (338-611): 6.36e-15: 81: 11.11
+	Hs
		521593 ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30		IGSF8_HUMAN (1-613): 5.61e-173: 507: 100.00
+	Hs
		725685 ACTN2_HUMAN (2-387): 2.32e-122: 412: 26.00		IGSF8_HUMAN (1-613): 5.61e-173: 507: 100.00
+	Hs
		211640 ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68		IGSF8_HUMAN (1-613): 5.61e-173: 507: 100.00
+	Hs
		521586 ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30		TITIN_HUMAN (169-612): 1.96e-12: 72.9: 9.60
+	Hs
		725681 ACTN2_HUMAN (2-387): 2.32e-122: 412: 26.00		TITIN_HUMAN (169-612): 1.96e-12: 72.9: 9.60
+	Hs
		255470 ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30		OBSL1_HUMAN (92-559): 2.57e-11: 69.3: 15.13
+	Hs
		211629 ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68		TITIN_HUMAN (169-612): 1.96e-12: 72.9: 9.60
+	Hs
		993278 ACTN3_HUMAN (23-388): 4.53e-120: 406: 27.63		TITIN_HUMAN (169-612): 1.96e-12: 72.9: 9.60
+	Hs
		211438 ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68		OBSL1_HUMAN (92-559): 2.57e-11: 69.3: 15.13
+	Dm
		574825 ACTN_DROME (1-386): 1.84e-105: 364: 25.90		TITIN_DROME (338-611): 6.36e-15: 81: 11.11
+	Hs
		255932 SYNE1_HUMAN (33-344): 6.35e-100: 364: 28.65		OBSL1_HUMAN (92-559): 2.57e-11: 69.3: 15.13
+	Hs
		363077 FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83		PGBM_HUMAN (22-166): 1.82e-12: 72.9: 14.84
+	Hs
		363240 FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83		TITIN_HUMAN (169-612): 1.96e-12: 72.9: 9.60