HitPredict

Interactor 1: FLNC (Q14315)
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
Gene: FLNC

Interactor 2: HSPB7 (Q9UBY9)
Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp)
Gene: HSPB7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 2725 Hs			1 170
+	Hs
		1052881 FLNC_HUMAN (1-2725): 0: 2507: 100.00		HSPB2_HUMAN (38-153): 2.85e-36: 125: 28.57
+	Hs
		598362 FLNA_HUMAN (167-2725): 0: 1226: 35.27		HSPB7_HUMAN (1-170): 3.64e-50: 160: 100.00
+	Hs
		261341 FLNB_HUMAN (146-2725): 0: 1198: 35.18		HSPB7_HUMAN (1-170): 3.64e-50: 160: 100.00
+	Hs
		261177 FLNB_HUMAN (146-2725): 0: 1198: 35.18		HSPB1_HUMAN (27-170): 1.44e-41: 139: 23.81
+	Dm
		946774 FLNA_DROME (758-2724): 0: 1012: 33.19		L2EFL_DROME (37-166): 1.82e-38: 131: 29.20
+	Hs
		388189 ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30		HSPB1_HUMAN (27-170): 1.44e-41: 139: 23.81
+	Hs
		388265 ACTN2_HUMAN (2-387): 2.32e-122: 412: 26.00		HSPB1_HUMAN (27-170): 1.44e-41: 139: 23.81
+	Hs
		211460 ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68		HSPB1_HUMAN (27-170): 1.44e-41: 139: 23.81
+	Hs
		725711 ACTN2_HUMAN (2-387): 2.32e-122: 412: 26.00		HSPB8_HUMAN (26-169): 1.86e-37: 129: 27.70
+	Mm
		1186643 ACTN1_MOUSE (13-382): 1.48e-122: 413: 26.30		HSPB2_MOUSE (38-153): 1.2e-32: 116: 28.57
+	Hs
		388383 SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12		HSPB1_HUMAN (27-170): 1.44e-41: 139: 23.81
+	Mm
		1143725 SPTB2_MOUSE (26-266): 1.26e-100: 365: 38.12		HSPB2_MOUSE (38-153): 1.2e-32: 116: 28.57
+	Dm
		113825 ACTN_DROME (1-386): 1.84e-105: 364: 25.90		M9NHC5_DROME (83-157): 4.65e-15: 70.3: 31.17
+	Hs
		362670 FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83		HSPB1_HUMAN (27-170): 1.44e-41: 139: 23.81
+	Mm
		984807 PGBM_MOUSE (1982-2725): 1.08e-22: 109: 12.63		HSPB2_MOUSE (38-153): 1.2e-32: 116: 28.57
+	Hs
		359052 TITIN_HUMAN (1554-2636): 3.13e-09: 65.5: 10.78		CRYAB_HUMAN (28-169): 1.17e-42: 141: 26.00
+	Hs
		1264819 TITIN_HUMAN (1554-2636): 3.13e-09: 65.5: 10.78		HSPB8_HUMAN (26-169): 1.86e-37: 129: 27.70
+	Hs
		1080881 TITIN_HUMAN (1554-2636): 3.13e-09: 65.5: 10.78		HSPB2_HUMAN (38-153): 2.85e-36: 125: 28.57