HitPredict

Interactor 1: FLNC (Q14315)
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
Gene: FLNC

Interactor 2: SYNP2 (Q9UMS6)
Synaptopodin-2 (Genethonin-2) (Myopodin)
Gene: SYNPO2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	20554076
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0030018 - Z disc
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2725 Hs			1 1093
+	Hs
		598375 FLNA_HUMAN (167-2725): 0: 1226: 35.27		SYNP2_HUMAN (1-1093): 5.3e-109: 367: 100.00
+	Hs
		598339 FLNA_HUMAN (167-2725): 0: 1226: 35.27		PDLI7_HUMAN (5-276): 3.88e-38: 151: 20.96
+	Hs
		598223 FLNA_HUMAN (167-2725): 0: 1226: 35.27		SYNPO_HUMAN (348-1089): 3.97e-33: 140: 18.48
+	Hs
		261295 FLNB_HUMAN (146-2725): 0: 1198: 35.18		SYNPO_HUMAN (348-1089): 3.97e-33: 140: 18.48
+	Hs
		725714 ACTN2_HUMAN (2-387): 2.32e-122: 412: 26.00		SYNP2_HUMAN (1-1093): 5.3e-109: 367: 100.00
+	Hs
		521616 ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30		SYP2L_HUMAN (343-1088): 2.65e-52: 201: 27.09
+	Hs
		725700 ACTN2_HUMAN (2-387): 2.32e-122: 412: 26.00		SYP2L_HUMAN (343-1088): 2.65e-52: 201: 27.09
+	Hs
		521502 ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30		PDLI4_HUMAN (9-299): 2.09e-44: 166: 19.27
+	Mm
		1186636 ACTN1_MOUSE (13-382): 1.48e-122: 413: 26.30		PDLI5_MOUSE (7-413): 7.78e-39: 155: 17.94
+	Hs
		521623 ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30		PDLI7_HUMAN (5-276): 3.88e-38: 151: 20.96
+	Hs
		725704 ACTN2_HUMAN (2-387): 2.32e-122: 412: 26.00		PDLI7_HUMAN (5-276): 3.88e-38: 151: 20.96
+	Hs
		521576 ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30		SYNPO_HUMAN (348-1089): 3.97e-33: 140: 18.48
+	Hs
		117245 ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30		PDLI1_HUMAN (8-299): 2.19e-34: 136: 19.86
+	Hs
		254383 ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30		LDB3_HUMAN (6-553): 6.13e-32: 135: 12.02
+	Hs
		117257 ACTN2_HUMAN (2-387): 2.32e-122: 412: 26.00		PDLI1_HUMAN (8-299): 2.19e-34: 136: 19.86
+	Rn
		1149817 ACTN1_RAT (13-382): 7.06e-123: 414: 26.30		PDLI2_RAT (7-313): 3.75e-33: 133: 15.99
+	Hs
		254385 ACTN2_HUMAN (2-387): 2.32e-122: 412: 26.00		LDB3_HUMAN (6-553): 6.13e-32: 135: 12.02
+	Mm
		1337461 ACTN2_MOUSE (2-387): 2.32e-122: 412: 26.00		LDB3_MOUSE (6-559): 2.04e-30: 131: 12.46
+	Hs
		521598 ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30		MAGI1_HUMAN (5-369): 2.81e-29: 128: 14.91
+	Hs
		725662 ACTN2_HUMAN (2-387): 2.32e-122: 412: 26.00		PDLI3_HUMAN (8-281): 1.24e-28: 120: 15.64