HitPredict

Interactor 1: FKBP8 (Q14318)
Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)
Gene: FKBP8

Interactor 2: ANKY2 (Q8IV38)
Ankyrin repeat and MYND domain-containing protein 2
Gene: ANKMY2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.695

Property	Details
Experiments	32877691, 28514442, 27770548, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0046872 - metal ion binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 412 Hs			1 441
+	Hs
		556701 FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00		ANK1_HUMAN (1-373): 3.28e-58: 208: 12.12
+	Hs
		883512 FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00		RIPK4_HUMAN (3-276): 1.34e-39: 153: 14.18
+	Hs
		1053188 FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00		Q9H4D1_HUMAN (3-276): 4.21e-39: 151: 14.18
+	Hs
		1034921 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		ANKY2_HUMAN (1-441): 8.31e-108: 327: 100.00
+	Hs
		1053168 FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00		TANC1_HUMAN (26-100): 1.24e-09: 62.8: 36.00
+	Hs
		259957 FKBP6_HUMAN (81-380): 6.91e-56: 188: 23.73		ZDH17_HUMAN (5-203): 8.27e-30: 124: 14.48
+	Hs
		883470 FKB1A_HUMAN (101-204): 1.72e-35: 128: 32.41		RIPK4_HUMAN (3-276): 1.34e-39: 153: 14.18
+	Hs
		923838 FKB1A_HUMAN (101-204): 1.72e-35: 128: 32.41		Q9H4D1_HUMAN (3-276): 4.21e-39: 151: 14.18
+	Hs
		1034903 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		POTEE_HUMAN (4-432): 3.34e-45: 170: 13.81
+	Hs
		883489 FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18		RIPK4_HUMAN (3-276): 1.34e-39: 153: 14.18
+	Hs
		972586 FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18		Q9H4D1_HUMAN (3-276): 4.21e-39: 151: 14.18
+	Hs
		684571 STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00		RIPK4_HUMAN (3-276): 1.34e-39: 153: 14.18
+	Hs
		685027 STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00		Q9H4D1_HUMAN (3-276): 4.21e-39: 151: 14.18
+	Hs
		883504 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		RIPK4_HUMAN (3-276): 1.34e-39: 153: 14.18
+	Hs
		1034995 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		Q9H4D1_HUMAN (3-276): 4.21e-39: 151: 14.18
+	Mm
		673842 FKBP4_MOUSE (72-404): 2.2e-24: 106: 18.86		ANS1B_MOUSE (3-341): 4.79e-33: 134: 17.06
+	Hs
		684893 STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00		ANKK1_HUMAN (139-378): 2.93e-14: 77.2: 8.84
+	Hs
		1034933 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		ANKK1_HUMAN (139-378): 2.93e-14: 77.2: 8.84