HitPredict

Interactor 1: GRB7 (Q14451)
Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
Gene: GRB7

Interactor 2: AGAP1 (Q9UPQ3)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1)
Gene: AGAP1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.80	0.587

Property	Details
Experiments	21900206
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	ArfGap~PH, PH~Ras, RA~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 532 Hs			1 857
+	Hs
		523208 SRC_HUMAN (351-528): 1.08e-46: 172: 24.32		AGAP1_HUMAN (1-857): 0: 850: 100.00
+	Rn
		499164 PLCG1_RAT (200-532): 1.02e-49: 186: 14.97		AGAP2_RAT (52-827): 0: 585: 53.27
+	Mm
		403434 SRC_MOUSE (351-528): 1.55e-46: 172: 24.32		AGAP2_MOUSE (53-827): 0: 579: 52.95
+	Gg
		94472 KSYK_CHICK (423-529): 5.2e-22: 101: 33.65		ACAP2_CHICK (308-854): 1.61e-133: 419: 18.01
+	Hs
		195785 PLCG1_HUMAN (200-532): 6.64e-50: 187: 14.69		ASAP2_HUMAN (367-855): 2.92e-95: 322: 19.77
+	Hs
		195776 FYN_HUMAN (357-529): 5.57e-50: 182: 20.88		ASAP2_HUMAN (367-855): 2.92e-95: 322: 19.77
+	Hs
		195777 YES_HUMAN (366-528): 8.94e-48: 175: 19.53		ASAP2_HUMAN (367-855): 2.92e-95: 322: 19.77
+	Hs
		195782 SRC_HUMAN (351-528): 1.08e-46: 172: 24.32		ASAP2_HUMAN (367-855): 2.92e-95: 322: 19.77
+	Hs
		581076 PLCG1_HUMAN (200-532): 6.64e-50: 187: 14.69		ASAP1_HUMAN (367-855): 1.34e-86: 300: 20.87
+	Hs
		412404 FYN_HUMAN (357-529): 5.57e-50: 182: 20.88		ASAP1_HUMAN (367-855): 1.34e-86: 300: 20.87
+	Hs
		523197 SRC_HUMAN (351-528): 1.08e-46: 172: 24.32		ASAP1_HUMAN (367-855): 1.34e-86: 300: 20.87
+	Hs
		411807 LCK_HUMAN (317-527): 2.74e-57: 200: 20.00		ARAP2_HUMAN (556-846): 2.29e-75: 271: 27.70
+	Hs
		442894 HCK_HUMAN (349-527): 4.62e-45: 168: 19.37		ASAP1_HUMAN (367-855): 1.34e-86: 300: 20.87
+	Hs
		412284 FYN_HUMAN (357-529): 5.57e-50: 182: 20.88		ARAP2_HUMAN (556-846): 2.29e-75: 271: 27.70
+	Hs
		433925 LYN_HUMAN (347-531): 4.7e-49: 178: 18.46		ARAP2_HUMAN (556-846): 2.29e-75: 271: 27.70
+	Hs
		581085 PLCG1_HUMAN (200-532): 6.64e-50: 187: 14.69		GIT1_HUMAN (616-848): 2.84e-73: 257: 31.58
+	Hs
		522992 SRC_HUMAN (351-528): 1.08e-46: 172: 24.32		ACAP1_HUMAN (306-788): 5.15e-74: 258: 15.47
+	Hs
		195791 GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89		ASAP2_HUMAN (367-855): 2.92e-95: 322: 19.77
+	Hs
		924943 GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89		ASAP1_HUMAN (367-855): 1.34e-86: 300: 20.87
+	Hs
		924582 GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89		ACAP1_HUMAN (306-788): 5.15e-74: 258: 15.47